NBDC Research ID: hum0563.v1
SUMMARY
Aims: Analysis of somatic mutational burden and immune-related gene expression to elucidate the detailed mechanisms of anti-tumor immune responses.
Methods: Whole exome sequencing, RNA sequencing
Participants/Materials: gastric cancer
| Dataset ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| JGAS000894 | NGS (Exome, RNA-seq) | Controlled-access (Type I) | 2026/04/16 |
*Data users need to apply an application for Using NBDC Human Data to reach the Controlled-access Data. Learn more
MOLECULAR DATA
| Participants/Materials |
gastric cancer (ICD10: C16): 10 cases paired tumor and non-tumor tissues (peripheral blood): 20 samples |
| Targets | Exome |
| Target Loci for Capture Methods | - |
| Platform | Illumina [NovaSeq 6000] |
| Library Source | DNA extracted from tumor tissues and peripheral blood cells |
| Cell Lines | - |
| Library Construction (kit name) | SureSelect Human All Exon V6 kit |
| Fragmentation Methods | Ultrasonic fragmentation |
| Spot Type | Paired-end |
| Read Length (without Barcodes, Adaptors, Primers, and Linkers) | 150 bp x 2 |
| Japanese Genotype-phenotype Archive Dataset ID | JGAD001038 |
| Total Data Volume | 325.4 GB（fastq） |
| Comments (Policies) | NBDC policy |
| Participants/Materials |
gastric cancer (ICD10: C16): 9 cases tumor tissues: |
| Targets | RNA-seq |
| Target Loci for Capture Methods | - |
| Platform | Illumina [NovaSeq 6000] |
| Library Source | RNA extracted from tumor tissues |
| Cell Lines | - |
| Library Construction (kit name) | TruSeq Stranded mRNA Sample Prep Kit |
| Fragmentation Methods | chemical fragmentation |
| Spot Type | Single-end |
| Read Length (without Barcodes, Adaptors, Primers, and Linkers) | 100 bp |
| Japanese Genotype-phenotype Archive Dataset ID | JGAD001038 |
| Total Data Volume | 325.4 GB（fastq） |
| Comments (Policies) | NBDC policy |
DATA PROVIDER
Principal Investigator: Shohei Koyama
Affiliation: Department of Immuno genomic medicine, National Cancer Center
Project / Group Name: Macrophage Reprogramming in Gastric Cancer
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| Moonshot Research and Development Program, Japan Agency for Medical Research and Development (AMED) | Actualization of a cancer-free society through regulation of chronic inflammation | JP22zf0127009 |
| Promotion of Cancer Research and Therapeutic Evolution, Japan Agency for Medical Research and Development (AMED) | Development of a novel immunotherapeutic strategy with sustained therapeutic effect by modulating the priming phase | JP23ama221329 |
| Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED) | Establishment of molecular target-immune integrated therapy targeting immunosuppressive molecules on cancer cells. | JP23ck0106796 |
| National Cancer Center Research and Development Fund | Establishment of specimen banking and comprehensive analysis platforms for advanced immunogenomic profiling | 2024-A-03 |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 | Lenvatinib combined with PD-1 blockade therapy benefits gastric cancers through immunosuppressive macrophage modulation | JGAD001038 | |
| 2 |
USRES (Controlled-access Data)
| Principal Investigator | Affiliation | Country/Region | Research Title | Data in Use (Dataset ID) | Period of Data Use |
|---|---|---|---|---|---|
