NBDC Research ID: hum0561.v1
SUMMARY
Aims: The association between tumor genomic alterations and clinical outcomes, including clinical and radiographic progression-free survival, PSA response, PSA progression-free survival, overall survival, and time to progression to castration-resistant prostate cancer (CRPC), was investigated in patients with metastatic castration sensitive prostate cancer (mCSPC) treated with the oral nonsteroidal antiandrogen enzalutamide. The findings are expected to contribute to the development of novel therapeutic strategies for personalized medicine in prostate cancer.
Methods: Whole exome sequencing analysis
Participants/Materials: 76 mCSPCs prior to enzalutamide treatment
| Dataset ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| JGAS000902 | NGS (Exome) | Controlled-access (Type I) | 2026/05/26 |
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MOLECULAR DATA
| Participants/Materials |
mCSPC (ICD10: C61) prior to enzalutamide treatment: 76 cases FFPE prostate biopsy specimens (tumor tissues): 76 samples peripheral blood cells (non-tumor tissues): 76 samples |
| Targets | Exome |
| Target Loci for Capture Methods | - |
| Platform | Illumina [NovaSeq 6000] |
| Library Source | DNAs extracted from tumor tissues and non-tumor tissues |
| Cell Lines | - |
| Library Construction (kit name) | SureSelect XT Human All Exon V6 kit |
| Fragmentation Methods | Ultrasonic fragmentation |
| Spot Type | Paired-end |
| Read Length (without Barcodes, Adaptors, Primers, and Linkers) | 150 bp |
| Japanese Genotype-phenotype Archive Dataset ID | JGAD001046 |
| Total Data Volume | 801.7 GB (fastq) |
| Comments (Policies) | NBDC policy |
DATA PROVIDER
Principal Investigator: Koji Hatano
Affiliation: Department of Urology, The University of Osaka Graduate School of Medicine
Project / Group Name: MENZ study group
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| Cancer Clinical Research Grant Program | A Prospective Multicenter Study of Exploring Genomic Correlates of Clinical Outcome in Patients with Metastatic Castration-Sensitive Prostate Cancer Receiving Enzalutamide | - |
| Astellas funding | A Prospective Multicenter Study of Exploring Genomic Correlates of Clinical Outcome in Patients with Metastatic Castration-Sensitive Prostate Cancer Receiving Enzalutamide | - |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 |
USRES (Controlled-access Data)
| Principal Investigator | Affiliation | Country/Region | Research Title | Data in Use (Dataset ID) | Period of Data Use |
|---|---|---|---|---|---|
