NBDC Research ID: hum0352.v1



Aims: To elucidate the functions of DNA repair proteins and RNA expression that are involved in the therapeutic efficacy and adverse events of radiotherapy for lung cancer. In particular, this is an exploratory study to identify proteins and RNAs involved in the expression of proteins that are likely to be involved in the prediction of radiotherapy response and adverse events.

Methods: Peripheral blood samples were collected from the patients with lung cancer who gave consent for this study. RNA-sequencing analysis was performed with the RNAs extracted from the blood samples.

Participants/Materials: Patients who have undergone radiotherapy for primary lung cancer at our hospital between 2019 and 2020 will be considered. Among them, we will include cases in which it is possible to determine the effect of treatment and evaluate adverse events before and, and whose blood can be drawn at 3 points: before radiotherapy, at the end of treatment, and 2-4 weeks after treatment.


Dataset IDType of DataCriteriaRelease Date
JGAS000545 NGS (RNA-seq) Controlled-access (Type I) 2022/09/20

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primary lung cancer (ICD10: C340): 5 cases

blood obtained before radiotherapy, at the end of treatment, and 2-4 weeks after treatment, 15 samples in total

Targets RNA-seq
Target Loci for Capture Methods -
Platform Illumina [NovaSeq 6000]
Library Source RNAs extracted from peripheral blood cells
Cell Lines -
Library Construction (kit name) TruSeq Stranded mRNA LT Sample Prep Kit
Fragmentation Methods TruSeq Stranded mRNA LT Sample Prep Kit
Spot Type Paired-end
Read Length (without Barcodes, Adaptors, Primers, and Linkers) 100 bp
Japanese Genotype-phenotype Archive Dataset ID JGAD000664
Total Data Volume 189.0 GB (fastq)
Comments (Policies) NBDC policy



Principal Investigator: Masanori Someya

Affiliation: Department of Radiology, Sapporo Medical University, School of Medicine

Project / Group Name: -

Funds / Grants (Research Project Number):

NameTitleProject Number
KAKENHI Grant-in-Aid for Scientific Research (C) Practical application of individualized radiotherapy using liquid biopsy 21K07680



TitleDOIDataset ID
1 Combined chemoradiotherapy and programmed cell death-ligand 1 blockade leads to changes in the circulating T-cell receptor repertoire of patients with non-small-cell lung cancer doi: 10.1111/cas.15566 JGAD000664


USRES (Controlled-access Data)

Principal InvestigatorAffiliationCountry/RegionResearch TitleData in Use (Dataset ID)Period of Data Use