NBDC Research ID: hum0314.v1
SUMMARY
Aims: The pathophysiology of Alzheimer's disease (AD) remains unclear and is limited to therapeutic approaches such as symptomatic drug intervention and rehabilitation / long-term care services to maintain the patient's quality of life. It has been shown that the genetic background is significantly involved in the development of sporadic AD. Pseudonymized information of the patient's cells and genotypes of them were compared with each other.
Methods: Genotyped with Infinium OmniExpressExome-8 v1.4 BeadChip according to manufacturer instructions
Participants/Materials: 102 patients with sporadic Alzheimer's disease
| Dataset ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| JGAS000383 | SNP array | Controlled-access (Type I) | 2021/11/19 |
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MOLECULAR DATA
| Participants/Materials | sporadic Alzheimer's disease (ICD10: G309, F009): 102 cases |
| Targets | genome wide SNPs |
| Target Loci for Capture Methods | - |
| Platform | Illumina [Infinium OmniExpressExome-8 v1.4 BeadChip] |
| Library Source | DNAs extracted from peripheral blood cells |
| Cell Lines | - |
| Reagents (Kit, Version) | Infinium OmniExpressExome-8 v1.4 BeadChip Kit |
| Genotype Call Methods (software) | GenCall software (GenomeStudio) |
| Marker Number | 962,215 SNVs (reference: 1,000 Genomes Project Phase 3） |
| Japanese Genotype-phenotype Archive Dataset ID | JGAD000498 |
| Total Data Volume | 4 GB (csv) |
| Comments (Policies) | NBDC policy |
DATA PROVIDER
Principal Investigator: Haruhisa Inoue
Affiliation: Center for iPS Cell Research and Applicatio (CiRA), Kyoto university
Project / Group Name: Laboratory of Stem Cell Medicine
URL: https://inoue.cira.kyoto-u.ac.jp/en/
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| Center for iPS Cell Research and Application, Kyoto University Management Expenses Grants | - | - |
| Center for Advanced Intelligence Project (AIP), RIKEN Management Expenses Grants | - | - |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 | Dissection of the polygenic architecture of neuronal Aβ production in Alzheimer’s disease using induced neurons from patient iPSCs | ||
| 2 |
USERS (Controlled-access Data)
| Principal Investigator | Affiliation | Country/Region | Research Title | Data in Use (Dataset ID) | Period of Data Use |
|---|---|---|---|---|---|
