NBDC Research ID: hum0272.v1
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SUMMARY
Aims: Analysis of gene expression and somatic gene mutation in tumor cells and immune cells using skin tumor samples such as melanoma
Methods: whole exome sequencing analysis, RNA sequencing analysis
Participants/Materials: melanoma patients: 4 cases
| Data Set ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| JGAS000285 | Controlled Access (Type I) | 2021/12/20 |
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MOLECULAR DATA
| Participants/Materials |
melanoma (ICD10: C439): 4 cases cultured tumor cells established from melanoma patients: 4 cases, 4 samples |
| Targets | Exome |
| Target Loci for Capture Methods | - |
| Platform | Illumina [HiSeq 2500] |
| Library Source | DNAs extracted from cultured tumor cells |
| Cell Lines | - |
| Library Construction (kit name) | Hybrid Selection |
| Fragmentation Methods | Captured / Adaptor ligation |
| Spot Type | Paired-end |
| Read Length (without Barcodes, Adaptors, Primers, and Linkers) | 92 bp (mean) |
| Japanese Genotype-phenotype Archive Data set ID | JGAD000391 |
| Total Data Volume | 99.6 GB (bam [ref: hg38]) |
| Comments (Policies) | NBDC policy |
| Participants/Materials |
melanoma (ICD10: C439): 4 cases cultured tumor cells established from melanoma patients: 4 cases, 4 samples |
| Targets | RNA-seq |
| Target Loci for Capture Methods | - |
| Platform | Illumina [HiSeq 2500] |
| Library Source | RNAs extracted from cultured tumor cells |
| Cell Lines | - |
| Library Construction (kit name) | Hybrid Selection |
| Fragmentation Methods | Captured / Adaptor ligation |
| Spot Type | Paired-end |
| Read Length (without Barcodes, Adaptors, Primers, and Linkers) | 100 bp (mean) |
| Japanese Genotype-phenotype Archive Data set ID | JGAD000391 |
| Total Data Volume | 99.6 GB (fastq) |
| Comments (Policies) | NBDC policy |
DATA PROVIDER
Principal Investigator: Takashi Inozume
Affiliation: Department of Dermatology, Chiba University
Project / Group Name: Development of more effective immunotherapy for skin cancer
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| KAKENHI Grant-in-Aid for Scientific Research (C) | Identification of essential biomarkers for efficacy of anti-PD-1 therapy | 19K08744 |
PUBLICATIONS
| Title | DOI | Data Set ID | |
|---|---|---|---|
| 1 | TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment | doi: 10.1136/jitc-2021-003134 | JGAD000391 |
| 2 |
USRES (Controlled-Access Data)
| Principal Investigator | Affiliation | Research Title | Data in Use (Data Set ID) | Period of Data Use |
|---|---|---|---|---|
