NBDC Research ID: hum0235.v1
SUMMARY
Aims: A study aiming to establish objective imaging and evaluation methods in preclinical Alzheimer's disease by collecting biochemical data such as psychological tests, MRI and PET images, and blood cerebrospinal fluid over time in patients with preclinical AD
Methods: We performed amyloid PET in healthy elderly and enrolled subjects with amyloid accumulation in the preclinical AD group. Subjects without amyloid accumulation were enrolled as healthy subjects. In addition, subjects who were diagnosed with MCI by psychological examination were enrolled. Those subjects underwent detailed psychological examination, MRI, FDG-PET, blood, and cerebrospinal fluid examination, and were followed up for 6 to 36 months.
Participants/Materials:
25 healthy elderly people without cognitive impairment
preclinical AD (ICD10: F00): 3 cases
early MCI (ICD10: F06.7): 7 cases
late MCI (ICD10: F06.7): 5 cases
URL: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000022596
| Dataset ID | Type of Data | Criteria | Release Date | |
|---|---|---|---|---|
|
1． |
Clinical and Psychometric Tests, Biochemical Tests, MRI Scan (1.5T, 3T), PET Scan (FDG, Amyloid (PIB, florbetapir, flutemetamol), Tau(flortaucipir)) |
Controlled-access |
2021/04/06 |
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2． |
List of Downloadable Files |
Unrestricted-access |
2021/04/06 |
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3． |
Data Dictionary（Description of each field in table data） |
Unrestricted-access |
2021/04/06 |
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4． |
Quality Control Procedures for MRI |
Unrestricted-access |
2021/04/06 |
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5． |
Quality Control Procedures for PET |
Unrestricted-access |
2021/04/06 |
* Restrictions on data use：NBDC policy
* Data users need to apply an application for Using NBDC Human Data to reach the Controlled-access Data. Learn more
* When the research results including the data which were downloaded from NHA/DRA, are published or presented somewhere, the data user must refer the papers which are related to the data, or include in the acknowledgment. Learn more
* Citation on publication for scientific papers using AMED-Pre data (see 'Other related information').
Data Summary
Dataset ID: JGAD000378 (13.9 GB)
１．Clinical and Psychometric Tests
| CRF Name | CRF Description | File Name | File Format（Extension） |
|---|---|---|---|
| ADAS*1 | ADAS-Cognitive Behavior | ADAS_AMED-Pre.csv | Comma-separated values (.csv) |
| ADASSCORES | ADAS Sub-Scores and Total Scores | ADASSCORES_AMED-Pre.csv | Comma-separated values (.csv) |
| ADSXLIST | Diagnosis and Symptoms Checklist | ADSXLIST_AMED-Pre.csv | Comma-separated values (.csv) |
| ARM | Diagnosis/Scan Category Assignment | ARM_AMED-Pre.csv | Comma-separated values (.csv) |
| BLCHANGE | Diagnostic Summary - Baseline Changes | BLCHANGE_AMED-Pre.csv | Comma-separated values (.csv) |
| BLSCHECK | Baseline Symptoms Checklist | BLSCHECK_AMED-Pre.csv | Comma-separated values (.csv) |
| CDR*2 | Clinical Dementia Rating | CDR_AMED-Pre.csv | Comma-separated values (.csv) |
| CONVERSIONS | Conversions Confirmed by Conversion Committee | CONVERSIONS_AMED-Pre.csv | Comma-separated values (.csv) |
| ECOG | Everyday Cognition Scale | ECOG_AMED-Pre.csv | Comma-separated values (.csv) |
| EXCLUSIO | Exclusion Criteria | EXCLUSIO_AMED-Pre.csv | Comma-separated values (.csv) |
| FAQ*3 | Functional Assessment Questionnaire | FAQ_AMED-Pre.csv | Comma-separated values (.csv) |
| FCSRT | Free and Cued Selective Reminding test (FCSRT) | FCSRT_AMED-Pre.csv | Comma-separated values (.csv) |
| FHQ | Family History Questionnaire | FHQ_AMED-Pre.csv | Comma-separated values (.csv) |
| GDSCALE*4 | Geriatric Depression Scale | GDSCALE_AMED-Pre.csv | Comma-separated values (.csv) |
| INCLUSIO | Inclusion Criteria | INCLUSIO_AMED-Pre.csv | Comma-separated values (.csv) |
| MEDHIST | Medical History | MEDHIST_AMED-Pre.csv | Comma-separated values (.csv) |
| MINT | Multilingual Naming Test | MINT-AMED-Pre.csv | Comma-separated values (.csv) |
| MMSE*5 | Mini Mental State Exam | MMSE_AMED-Pre.csv | Comma-separated values (.csv) |
| MODHACH*6 | Modified Hachinski | MODHACH_AMED-Pre.csv | Comma-separated values (.csv) |
| NEUROBAT | Neuropsychological Battery | NeuroBAT_AMED-Pre.csv | Comma-separated values (.csv) |
| NEUROEXM | Neurological Exam | NEUROEXM_AMED-Pre.csv | Comma-separated values (.csv) |
| NPI12*7 | Neuropsychiatric Inventory Q | NPI12_AMED-Pre.csv | Comma-separated values (.csv) |
| PDXCONV | Diagnostic Summary | PDXCONV_AMED-Pre.csv | Comma-separated values (.csv) |
| PHYSICAL | Physical Exam | PHYSICAL_AMED-Pre.csv | Comma-separated values (.csv) |
| PTDEMOG | Participant Demographic Information | PTDEMOG_AMED-Pre.csv | Comma-separated values (.csv) |
| RECFHQ | Family History Questionnaire Subtable | RECFHQ_AMED-Pre.csv | Comma-separated values (.csv) |
| REGISTRY | Registry | REGISTRY_AMED-Pre.csv | Comma-separated values (.csv) |
| TREATDIS | Early Discontinuation and Withdrawal | TREATDIS_AMED-Pre.csv | Comma-separated values (.csv) |
| VITALS | Vital Signs | VITALS_AMED-Pre.csv | Comma-separated values (.csv) |
※1：Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. The American Journal of Psychiatry. 1984;141(11):1356–1364. PMID 6496779
※2：Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br J Psychiatry. 1982 Jun;140:566-72. PMID 7104545
※3：Pfeffer RI, Kurosaki TT, Harrah CH, Chance JM, Filos S. Measurement of functional activities in older adults in the community. J Gerontol. 1982;37:323–329. PMID 7069156
※4：Yesavage JA, Brink TL, Rose TL, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982-83;17(1):37-49. PMID 7183759
※5：Folstein, MF; Folstein, SE; McHugh, PR (1975). ""Mini-mental state". A practical method for grading the cognitive state of patients for the clinician". Journal of Psychiatric Research 12 (3): 189–98. PMID 1202204
※6：Hachinski VC. Multi-infarct dementia: a cause of mental deterioration in the elderly. Lancet. 1974;2:207–9. PMID 4135618
※7：Cummings, J., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994). The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia. Neurology, 44, 2308-2314. PMID 7991117
2．Biochemical Tests
| CRF Name | CRF Description | File Name | File Format（Extension） |
|---|---|---|---|
| APOE | ApoE Genotyping | APOE_AMED-Pre.csv | Comma-separated values (.csv) |
| BLOOD | Perpheral Blood | BLOOD_AMED-Pre.csv | Comma-separated values (.csv) |
| CSF | Cerebrospinal Fluid (CSF) | CSF_AMED-Pre.csv | Comma-separated values (.csv) |
3．MRI scan
3.1 Quality Control
| CRF Name | CRF Description | File Name | File Format（Extension） |
|---|---|---|---|
| MRIQC | MRI Scan Information | MRIQC-AMED-Pre.csv | Comma-separated values (.csv) |
※ See MRIDOC for MRI quality control procedures
3.2 MRI Images
| Description | File Name | File Format（Extension） |
|---|---|---|
| Raw MRI Images obtained from MRI Scanners | DICOM |
4. PET Scan (FDG, Amyloid (PIB, florbetapir, flutemetamol), Tau(flortaucipir))
4.1 Quality Control
| CRF Name | CRF Description | File Name | File Format（Extension） |
|---|---|---|---|
| PETQC | PET Scan Information | PETQC-AMED-Pre.csv | Comma-separated values (.csv) |
※ See PETDOC for PET quality control procedures.
4.2 PET Images
| Description | File Name | File Format（Extension） |
|---|---|---|
| PET Images | DICOM |
DATA PROVIDER
Principal Investigator: Hiroyuki Shimada
Affiliation: Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine
Project / Group Name: AMED Preclinical AD study group (Clinical Sites, Citation Information [see 'Other related information'])
URL： https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000022596
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| Research and Development Grants for Dementia, Japan Agency for Medical Research and Development (AMED) | Evaluation and imaging study of the preclinical stage of Alzheimer's disease in Japan | JP19dk0207020 |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 | A Japanese Multicenter Study on PET and Other Biomarkers for Subjects with Potential Preclinical and Prodromal Alzheimer’s Disease | doi: 10.14283/jpad.2021.37 | JGAD000378 |
USRES (Controlled-access Data)
| Principal Investigator | Affiliation | Country/Region | Research Title | Data in Use (Dataset ID) | Period of Data Use |
|---|---|---|---|---|---|
| Yasuhiko Ikari | Molecular Imaging Center for Clinical Research and Innovation, Kobe City Medical Center General Hospital | Development of imaging biomarkers on clinical study image database for Alzheimers disease. | JGAD000378 | 2021/06/14-2023/03/31 |
