NBDC Research ID: hum0167.v1
SUMMARY
Aims: To clarify the susceptibility genetic loci for serum uric acid (SUA) level
Methods: GWAS meta analysis
Participants/Materials: Participants of 3 Japanese cohorts (the Japan Multi-Institutional Collaborative Cohort [J-MICC] study, the KIta Nagoya Genomic epidemiological studies [KING] study, and the Bio Bank Japan [BBJ] study)
| Dataset ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| hum0167.v1.meta.v1 | meta analysis of 3 GWASs for SUA level | Unrestricted-access | 2019/07/23 |
*When the research results including the data which were downloaded from NHA/DRA, are published or presented somewhere, the data user must refer the papers which are related to the data, or include in the acknowledgment. Learn more
MOLECULAR DATA
| Participants/Materials |
[GWAS-1] - J-MICC study: 10,621 participants [GWAS-2] - KING study: 2,095 participants [GWAS-3] - BBJ: 109,029 participants |
| Targets | genome wide SNVs |
| Target Loci for Capture Methods | - |
| Platform | Illumina [HumanOmniExpressExome-8, 660W-Quad, Omni2.5-8, OmniExpress-12, OmniExpress-24, HumanOmniExpressExome, HumanOmniExpress, HumanExome BeadChip] |
| Source | gDNA extracted from peripheral blood cells |
| Cell Lines | - |
| Reagents (Kit, Version) | HumanOmniExpressExome-8, 660W-Quad, Omni2.5-8, OmniExpress-12, OmniExpress-24, HumanOmniExpressExome, HumanOmniExpress, HumanExome BeadChip kit |
| Genotype Call Methods (software) |
SHAPEIT3 & minimac3 (1000G phase3v5; individuals of all ancestry) / MACH & minimac (1000G phase1v3; individuals of East Asian ancestry) GenomeStudio / BeadStudio |
| Association Analysis (software) |
EPACTS / mach2qtl METAL |
| Filtering Methods | Post-imputation QC: Variants with imputation quality of Rsq < 0.7 in BBJ or Rsq < 0.3 in others were excluded. We also excluded variants with MAF < 0.005. |
| Marker Number (after QC) | 5,864,938 SNPs (hg19) |
| NBDC Dataset ID |
(Click the Dataset ID to download the file) |
| Total Data Volume | 80 MB (tsv.zip) |
| Comments (Policies) | NBDC policy |
DATA PROVIDER
Principal Investigator: Hirotaka Matsuo
Affiliation: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College
Project / Group Name:
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| KAKENHI Grant-in-Aid for Scientific Research (B) | Investigation of pathophysiology of gout by molecular genetic epidemiological analysis and application to genome-tailored medicine | 25293145 |
| KAKENHI Grant-in-Aid for challenging Exploratory Research | Evaluation of urate excretion mechanism at human intestinal epithelium using molecular genetic epidemiological analysis | 15K15227 |
| KAKENHI Grant-in-Aid for Scientific Research (B) | Organization of International consortium for gout genetics and development of its preventive medicine | 17H04128 |
| KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area) | Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas Study on supports for molecular cohort studies | 221S0001 |
| KAKENHI Grant-in-Aid for Scientific Research on Priority Areas | Study on supports for molecular cohort studies | 17015018 |
| KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources | Platform of Supporting Cohort Study and Biospecimen Analysis | 16H06277 |
| KAKENHI Grant-in-Aid for Scientific Research (B) | Prediction of the genetic and epigenetic risk associated with lifestyle-relatied diseases in the population-based confirmatory factor analysis | 24390169 |
| KAKENHI Grant-in-Aid for Scientific Research (B) | Prediction of the genetic and epigenetic risks associated with lifestyle-related diseases in the population-based confirmatory factor analysis | 16H05250 |
| KAKENHI Grant-in-Aid for Scientific Research (B) | Construction of an epigenetic epidemiology database for a population cohort | 25293144 |
| KAKENHI Grant-in-Aid for Young Scientists (B) | Elucidation of adiponectin expression pathway based on the co-expression network and epigenome data analysis | 15K19242 |
| KAKENHI Grant-in-Aid for Scientific Research (C) | Elucidation of the significance of DNA methylation at the ELOVL2 promoter for the proposal of new metabolic correlations | 18K06942 |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 | Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals | doi: 10.1038/s42003-019-0339-0 | hum0167.v1.meta.v1 |
| 2 |
