NBDC Research ID: hum0061.v1



Aims: To identify causative genetic aberrations in multiple primary lung cancer

Methods: Whole exome sequencing (Illumina HiSeq 2000)

Participants/Materials: Siblings developed multiple primary lung cancers


Dataset IDType of DataCriteriaRelease Date
JGAS000057 NGS (Exome) Controlled-access (Type I) 2017/02/20

*Release Note 

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Participants/Materials Siblings developed multiple primary lung cancers
Targets Exome
Target Loci for Capture Methods -
Platform Illumina [HiSeq 2000]
Library Source gDNA extracted from peripheral blood cells of siblings developed multiple primary lung cancers
Cell Lines -
Library Construction (kit name) BGI exome sequencing service
Fragmentation Methods BGI exome sequencing service
Spot Type Paired-end
Read Length (without Barcodes, Adaptors, Primers, and Linkers) 90 bp
Japanese Genotype-phenotype Archive Dataset ID JGAD000057
Total Data Volume

29 GB

  Data files: 8 (fastq)

  Analysis files: 4 (vcf [ref: hg19])

Comments (Policies) NBDC policy



Principal Investigator: Kikuya Kato

Affiliation: Osaka Medical Center for Cancer and Cardiovascular Diseases

Project / Group Name: -

Funds / Grants (Research Project Number):

NameTitleProject Number
KAKENHI Grant-in-Aid for Scientific Research (C) Identification of causative genes for hereditary cancer by genome analyses of familial cancer cases and its application 25430180
The Osaka Community Foundation Searching causative genes of familial or sporadic rare tumors using whole gene sequencing -
The Charitable Trust Osaka Cancer Research Foundation Searching causative genetic aberrations of familial or sporadic rare tumors by genome analyses of patients -
The Osaka Medical Research Foundation for Intractable Diseases Searching causative genes of familial cancers by genome analyses of sibling patients with rare cancer -



TitleDOIDataset ID
1 Homozygous inactivation of CHEK2 is linked to a familial case of multiple primary lung cancer with accompanying cancers in other organs doi: 10.1101/mcs.a001032 JGAD000057


USRES (Controlled-access Data)

Principal InvestigatorAffiliationCountry/RegionResearch TitleData in Use (Dataset ID)Period of Data Use
Hirofumi Nakaoka Department of Cancer Genome Research, Sasaki Institute Japan Genetic analysis of lung cancer JGAD000057 2022/08/06-2023/03/31