NBDC Research ID: hum0013.v1
SUMMARY
Aims: To build a Japanese control DNA database for application to genetic investigations on adverse drug reactions and facilitate in the development of drugs with high efficacy and safety.
Methods: Determine the genotype of nearly 2.5 million single nucleotide polymorphisms (SNPs) by using of illumina HumanOmni2.5-8.
Participants/Materials: 2994 Japanese healthy controls
URL: JPDSC
| Dataset ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| hum0013.v1.freq.v1 | genotype counts of 2.5 million SNPs | Unrestricted-access | 2014/10/16 |
*When the research results including the data which were downloaded from NHA/DRA, are published or presented somewhere, the data user must refer the papers which are related to the data, or include in the acknowledgment. Learn more
MOLECULAR DATA
| Participants/Materials | 2994 Japanese healthy controls |
| Targets | genome wide SNPs |
| Target Loci for Capture Methods | - |
| Platform | Illumina [HumanOmni2.5-8 BeadChip] |
| Source | DNAs extracted from peripheral blood |
| Cell Lines | - |
| Reagents (Kit, Version) | HumanOmni2.5-8 v1.0 BeadChip Kit |
| Genotype Call Methods (softwares) | GenomeStudio |
| Filtering Methods | Call Rate ≧ 0.95 and HWE ≧ 0.001 |
| Marker Number (after QC) | 2,343,307 SNVs |
| NBDC Dataset ID |
(Click the Dataset ID to download the file) |
| Total Data Volume | 68.9 MB (zip [txt]) |
| Comments (Policies) | NBDC policy |
DATA PROVIDER
Principal Investigator: Koji Suematsu
Affiliation: PGx, Clinical Research, Taisho Pharmaceutical Co., Ltd.
Project / Group Name: The Japan PGx Data Science Consortium (JPDSC)
URL: https://doi.org/10.1038/jhg.2015.23
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| - | - | - |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 | Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects. | doi:10.2217/pgs.13.180 | hum0013.v1.freq.v1 |
| 2 | A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. | doi:10.1038/tpj.2011.41 | hum0013.v1.freq.v1 |
