NBDC Research ID: hum0004.v1
SUMMARY
Aims: Molecular epidemiological study of somatic mutation profiles of epidermal growth factor receptor: EGFR mutation-positive lung adenocarcinoma
Methods: Whole Genome Sequence (Illumina [Genome Analyzer IIx])
Participants/Materials: 97 Japanese lung adenocarcinoma patients as tumor-normal pairs.
| Dataset ID | Type of Data | Criteria | Release Date |
|---|---|---|---|
| JGAS000001 | NGS (Exome) | Controlled-access (Type I) | 2014/07/11 |
* Data users need to apply an application for Using NBDC Human Data to reach the Controlled-access Data. Learn more
MOLECULAR DATA
| Participants/Materials | 97 Japanese lung adenocarcinoma patients as tumor-normal pairs |
| Targets | Exome |
| Target Loci for Captur Methods | - |
| Platforms | Illumina [Genome Analyzer IIx] |
| Library Sources | DNAs extracted from adenocarcinoma and non-adenocarcinoma |
| Cell Lines | - |
| Library Construction (kit name) | SureSelect Target Enrichment System |
| Fragmentation Methods | Ultrasonic fragmentation (Covaris) |
| Spot Type | Paired-end reads |
| Read Length (without Barcodes, Adaptors, Primers, and Linkers) | 76 bp x 2 |
| Japanese Genotype-phenotype Archive Dataset ID | JGAD000001 |
| Total Data Volume | |
| Comments (Policies) | NBDC policy & hum0004 policy |
DATA PROVIDER
Principal Investigator: Koichi Goto
Affiliation: Thoracic Oncology Division, the National Cancer Center Hospital East
Project / Groupe Name: Division of Translational Informatics, the Exploratory Oncology Research & Clinical Trial Center, the National Cancer Center
URL： https://www.ncc.go.jp/en/epoc/division/translational_informatics/kashiwa/index.html
Funds / Grants (Research Project Number):
| Name | Title | Project Number |
|---|---|---|
| KAKENHI Grant-in-Aid for Scientific Research (B) | Searching for kinases related to lung cancer based on genomic analysis for lung adenocarcinoma | 24300345 |
PUBLICATIONS
| Title | DOI | Dataset ID | |
|---|---|---|---|
| 1 | Identification and characterization of cancer mutations in Japanese lung adenocarcinoma without sequencing of normal tissue counterparts. | doi: 10.1371/journal.pone.0073484 | JGAD000001 |
| 2 | Clinicopathological characteristics of EGFR mutated adenosquamous carcinoma of the lung. | doi: 10.1111/pin.12033 | |
| 3 | Immunohistochemical and genetic characteristics of lung cancer mimicking organizing pneumonia. | doi: 10.1016/j.lungcan.2017.10.001 | |
| 4 | Podoplanin-positive cancer-associated fibroblast recruitment within cancer stroma is associated with a higher number of single nucleotide variants in cancer cells in lung adenocarcinoma. | doi: 10.1007/s00432-018-2619-3 | |
| 5 | Characterization of the tumor immune-microenvironment of lung adenocarcinoma associated with usual interstitial pneumonia. | doi: 10.1016/j.lungcan.2018.11.006 |
USERS (Controlled-access Data)
| Principal Investigator | Affiliation | Country/Region | Research Title | Data in Use (Dataset ID) | Period of Data Use |
|---|---|---|---|---|---|
| Youping Deng | Department of Complementary and Integrative Medicine, University of Hawai Manoa | JGAD000001 | 2018/10/04-2025/07/10 | ||
| Hirofumi Nakaoka | Department of Cancer Genome Research, Sasaki Institute | Japan | Genetic analysis of lung cancer | JGAD000001 | 2022/08/06-2023/03/31 |
