NBDC Research ID: hum0372.v1

 

SUMMARY

Aims: To elucidate the genetic predisposition to metabolic syndrome-related diseases such as diabetes and the genetic predisposition to reactivity and side effects of diabetes drugs in Japanese people, and to apply this to the prevention of diabetes and personalized medicine.

Methods: We profiled serum metabolites of persons with type 2 diabetes (T2D) with or without diabetic complications using a comprehensive non-targeted metabolomics approach with mass spectrometry. The abundance of the 364 serum metabolites was compared between the T2D patients with multiple complications (N = 141) and those without any complications (N = 159), then calculated the summary statistics.

Participants/Materials: T2D

 

Dataset IDType of DataCriteriaRelease Date
JGAS000572 the abundance of the 364 serum metabolites Controlled-access (Type I) 2022/11/22
MTBKS213, MTBKS214 the summary statistics Unrestricted-access 2022/11/22

*Release Note

* Data users need to apply an application for Using NBDC Human Data to reach the Controlled-access Data. Learn more

*When the research results including the data which were downloaded from MataboBank, are published or presented somewhere, the data user must refer the papers which are related to the data, or include in the acknowledgment. Learn more

 

MOLECULAR DATA

JGAS000572 / MTBKS213 / MTBKS214

Participants/Materials

T2D without diabetic complications (ICD10: E11): 159 cases

T2D with both diabetic kidney disease and diabetic retinopathy (ICD10: E11): 141 cases

Targets metabolome
Target Loci for Capture Methods -
Platform

Agilent Technologies [Agilent CE system equipped with an Agilent 6210 TOFMS, Agilent 1100 isocratic HPLC pump]

Agilent Technologies [Agilent LC System equipped with an Agilent 6230 TOFMS]

Source Serum
Cell Lines -
Measurement Method

Agilent Technologies [Agilent CE system equipped with an Agilent 6210 TOFMS, Agilent 1100 isocratic HPLC pump]

Agilent Technologies [Agilent LC System equipped with an Agilent 6230 TOFMS]

Measurement Conditions (Parameters) -
Noise reduction & Data correction -
Annotation -
Quantification Methods (software) -
Metabolic biomarkers 364 serum metabolites
Japanese Genotype-phenotype Archive Dataset ID JGAD000698
MetaboBank Accession ID

CE-MS: MTBKS213

LC-MS: MTBKS214

Total Data Volume

JGAD000698: 2.1 MB (txt)

MTBKS213 / MTBKS214: 39 KB (tsv)

Comments (Policies) NBDC policy

 

DATA PROVIDER

Principal Investigator: Toshimasa Yamauchi 1 / Takashi Kadowaki 1,2 / Yukinori Okada 3

Affiliation: 1. Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo

                   2. Toranomon Hospital

                   3. Department of Statistical Genetics, Graduate School of Medicine, Osaka University

Project / Group Name: Social implementation of next-generation precision medicine from Japan based on comprehensive analysis of genetic and environmental factors of diabetes

Funds / Grants (Research Project Number):

NameTitleProject Number
Platform Program for Promotion of Genome Medicine, Japan Agency for Medical Research and Development (AMED) Realization of next-generation precision medicine from Japan based on comprehensive analysis of genetic and environmental factors of diabetes JP20km0405202
Platform Program for Promotion of Genome Medicine, Japan Agency for Medical Research and Development (AMED) Social implementation of next-generation precision medicine from Japan based on comprehensive analysis of genetic and environmental factors of diabetes JP21tm0424218

 

PUBLICATIONS

TitleDOIDataset ID
1 Identification of serum metabolome signatures associated with retinal and renal complications of type 2 diabetes doi: 10.1038/s43856-022-00231-3 JGAD000698
MTBKS213
MTBK214
2

 

USRES (Controlled-access Data)

Principal InvestigatorAffiliationCountry/RegionResearch TitleData in Use (Dataset ID)Period of Data Use