# Genome-wide summary statistics for gene-environment (GxE) interactions


## Files
Files are bgzipped and named in the format of "${cohort}.${phenotype_category}.${phenotype}.${environment}.txt.gz".

The cohorts are either BBJ1 (the Japanese population) or UKB1 (the British European population).
See the metadata for the description of the phenotypes and the environments.

As the files are bgzipped, users can create their index files using tabix.
Missing values are coded as "#NA", following the GWAS-SSF format.


## Columns

* chromosome: chromosome
* base_pair_location: position
* effect_allele: effect alleles
* other_allele: other alleles
* beta: effect sizes of GxE interactions (missing if multiple GxE terms were tested jointly)
* standard_error: standard errors (missing if multiple GxE terms were tested jointly)
* effect_allele_frequency: effect allele frequencies
* p_value: p-values of GxE interactions
* rsid: rsID (optional)
* variant_id: internal variant ID
* n: Number of samples
* beta_interaction_${environment}: effect sizes of individual GxE interactions (for joint tests of multiple GxE terms)
* standard_error_interaction_${environment}: standard errors of individual GxE interactions (for joint tests of multiple GxE terms)
* beta_marginal: effect sizes of marginal effects
* standard_error_marginal: standard errors for the effect sizes of marginal effects
* beta_genotype: effect sizes of genotype effects
* standard_error_genotype: standard errors for the effect sizes of genotype effects
* p_value_marginal: p-values of marginal effects
* p_value_joint: p-values of joint tests for marginal effects and GxE interactions


## General 

* Genome assembly: GRCh37
* Genotyping technology: Genome-wide genotyping array, imputed
* MAF lower limit: 0.01
* Analysis Software: GEM