This data set provides the summary statistics of Smoking behaviors in the BioBank Japan Project
(Matba N. et al., Nat Hum. Behav. (2019)).
Smoking behaviors include four phenotypes:
| Trait (Full name) | Trait (Abbr.) | SEX | Type | # Case | # Control | # Total |
|---|---|---|---|---|---|---|
| Age of smoking initiation | AI | All | QTL | 30,418 | ||
| Age of smoking initiation | AI | Male | QTL | 23,039 | ||
| Age of smoking initiation | AI | Female | QTL | 7,379 | ||
| Cigarettes per day | CPD | All | QTL | 72,655 | ||
| Cigarettes per day | CPD | Male | QTL | 58,784 | ||
| Cigarettes per day | CPD | Female | QTL | 13,871 | ||
| Smoking initiation | EVERSMK | All | Case-Control | 83,810 | 81,626 | 165,436 |
| Smoking initiation | EVERSMK | Male | Case-Control | 67,773 | 21,905 | 89,638 |
| Smoking initiation | EVERSMK | Female | Case-Control | 16,077 | 59,721 | 75,798 |
| Smoking cessation | FORMER | All | Case-Control | 43,163 | 32,884 | 76,047 |
| Smoking cessation | FORMER | Male | Case-Control | 36,787 | 24,909 | 61,696 |
| Smoking cessation | FORMER | Female | Case-Control | 6,376 | 7,975 | 14,351 |
20 summary statistics were included in this data set.
- 4 traits x 3 set (all, male and female) autosomes
- 4 traits x 2 set (male and female) Xchromosomes
| File Names | # variants |
|---|---|
| ${SEX}_2018_${Trait}_BBJ_autosome_Pcorrected.txt.gz | 5,961,480 |
| Male_2018_AI_BBJ_Xchromosome_Pcorrected.txt.gz | 163,412 |
| Female_2018_AI_BBJ_Xchromosome_Pcorrected.txt.gz | 146,130 |
| Male_2018_CPD_BBJ_Xchromosome_Pcorrected.txt.gz | 166,111 |
| Female_2018_CPD_BBJ_Xchromosome_Pcorrected.txt.gz | 146,114 |
| Male_2018_EVERSMK_BBJ_Xchromosome_Pcorrected.txt.gz | 166,138 |
| Female_2018_EVERSMK_BBJ_Xchromosome_Pcorrected.txt.gz | 146,146 |
| Male_2018_FORMER_BBJ_Xchromosome_Pcorrected.txt.gz | 166,142 |
| Female_2018_FORMER_BBJ_Xchromosome_Pcorrected.txt.gz | 146,118 |
| Column | Description | |
|---|---|---|
| 1 | SNP | rs number or ID string |
| 2 | CHR | chromosome |
| 3 | POS | physical position (hg19) |
| 4 | A1 | effect allele |
| 5 | A2 | other allele |
| 6 | A1Frq | frquency of effect allele |
| 7 | Rsq | imputation quality |
| 8 | BETA | effect size from BOLT-LMM approximation to infinitestimal mixed model |
| 9 | SE | standard error of effect size |
| 10 | P | LDSC-intercept corrected infinitestimal mixed model association test p-value |
When using these summary statistics, please cite the following paper.
Matoba N et al., GWAS of smoking behavior in 165,436 Japanese revealed seven new loci and shared genetic architecture
Nat. Hum. Behav. (2019)
JENGER (the lab website)
The biobank Japan project
National Bioscience Database Center Human Database
RIKEN Center for Integrative Medical Sciences