2018 Primary open-angle glaucoma (POAG) GWAS results in the Biobank Japan project

Descrption:

These files were the results of GWAS for POAG in the Biobank Japan project released via National Bioscience Database Center (NBDC).

Uploaded file:

File name Number of cases Number of controls Number of variants
2018_POAG_BBJ_autosome.txt.gz 3,980 18,815 5,961,428
Male_2018_POAG_BBJ_Xchromosome.txt.gz 1,997 7,817 147,351
Female_2018_POAG_BBJ_Xchromosome.txt.gz 1,983 10,998 147,353

In the uploaded files, variants with |beta| > 4 were excluded.

Column:

Number of column column description
1 SNP marker name
2 CHR chromosome
3 POS position (hg19)
4 REF reference allele
5 ALT alternative allele
6 Case_frq alternative allele frequency in cases
7 Ctrl_frq alternative allele frequency in controls
8 Rsq imputation quality
9 BETA beta
10 OR odds ratio
11 SE standard error
12 P P-value

・　Alternative alleles were used as effect alleles.
・　Association analysis was performed using mach2dat software (Li Y. et al, Genet. Epidemiol. 2010).

Link:

The biobank Japan project
National Bioscience Database Center Human Database
RIKEN Center for Integrative Medical Sciences

Reference:

If you use these date, please cite the following paper:
Shiga Y et al. Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma.
Hum. Mol. Genet. (2018). DOI: 10.1093/hmg/ddy053