{"id":"hum0615","version":1,"url":"https://humandbs.dbcls.jp/research/hum0615/v1","datePublished":"2026-10-23","versions":[{"version":1,"datePublished":"2026-10-23"}],"title":{"ja":"消化器悪性腫瘍・前がん病変に対する遺伝子解析研究","en":"Genomic Analysis of Digestive System Malignancies and Precancerous Lesions"},"summary":{"aims":{"ja":"京都大学医学部附属病院における消化器悪性腫瘍、および消化器前がん病変の遺伝子変異を網羅的に検証し、遺伝子プロファイルと臨床病理学的因子の関係性を明らかにする。","en":"To comprehensively characterize genetic alterations in digestive system malignancies and premalignant lesions at Kyoto University Hospital and elucidate the associations between their genetic profiles and clinicopathological factors."},"methods":{"ja":"胆管内乳頭状腫瘍（IPNB）の手術検体から非癌部および癌部組織を採取した。DNAを抽出し、全エクソン解析を行った。","en":"Tumor and matched non-tumor tissues were collected from surgically resected IPNB specimens. DNA was extracted from each tissue sample and subjected to whole-exome sequencing."},"targets":{"ja":"胆管内乳頭状腫瘍（intraductal papillary neoplasms of the bile duct：IPNB）：10症例\n腫瘍組織：22検体、非腫瘍組織：10検体","en":"intraductal papillary neoplasm of the bile duct (IPNB): 10 cases\n22 tumor tissues and 10 matched non-tumor tisuues"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"胆管内乳頭状腫瘍：10症例","en":"IPNB: 10 cases"},"typeOfData":{"ja":"NGS（Exome）","en":"NGS (Exome)"}},"releaseNote":{"ja":"胆管内乳頭状腫瘍10症例の腫瘍組織および非腫瘍組織から抽出したDNAを用いたwhole-exome sequencing解析結果をfastqファイルにて提供する。","en":"DNA extracted from tumor tissues and non-tumor tissues of 10 intraductal papillary neoplasms of the bile duct (IPNB) patients were used for the whole exome sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"石井 隆道","en":"Takamichi Ishii"},"organization":{"name":{"ja":"京都大学大学院 医学研究科 消化器腫瘍制御・臓器再生外科学講座","en":"Department of Surgery for Abdominal Oncology and Organ Regeneration, Graduate School of Medicine, Kyoto University"}}}],"researchProjects":[{"name":{"ja":null,"en":null},"url":{"ja":[{"url":"https://hbptsurgery.kuhp.kyoto-u.ac.jp/study/liver-regeneration-research/","text":"https://hbptsurgery.kuhp.kyoto-u.ac.jp/study/liver-regeneration-research/"}],"en":null}}],"grants":[{"title":{"ja":"新規治療法を目指した細胆管細胞癌の臨床病理学解析およびゲノム解析による統合解析","en":"Integrated Clinicopathological and Genomic Analysis of Cholangiolocellular Carcinoma Aimed at Developing Novel Therapeutic Strategies"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["24K11864"]},{"title":{"ja":"ゲノム変異に基づいたIPNBから胆管癌への進行過程の探索","en":"Investigation of the Progression from Intraductal Papillary Neoplasm of the Bile Duct to Cholangiocarcinoma Based on Genomic Alterations"},"agency":{"ja":"一般財団法人藤原記念財団 少壮研究者奨励金","en":"Fujiwara Memorial Foundation Research Grant"},"grantIds":["NA"]}],"relatedPublications":[],"datasets":["JGAD001128"],"controlledAccessUsers":[]}