{"id":"hum0600","version":1,"url":"https://humandbs.dbcls.jp/research/hum0600/v1","datePublished":"2026-09-17","versions":[{"version":1,"datePublished":"2026-09-17"}],"title":{"ja":"シングルセル遺伝子発現解析による進行性甲状腺癌の分子機構の解明","en":"Elucidation of the Molecular Mechanisms of Advanced Thyroid Cancer through Single-Cell Gene Expression Analysis"},"summary":{"aims":{"ja":"進行性甲状腺がん（甲状腺未分化がん、甲状腺低分化がん、進行・再発甲状腺分化がん）よりシングルセル遺伝子発現解析を行い、甲状腺がんの悪性化・未分化転化に関与する遺伝子を検索し、またがん微小環境を構築する細胞群の特徴を解析する。","en":"We will perform single-cell gene expression analysis on advanced thyroid cancer (undifferentiated thyroid carcinoma, poorly differentiated thyroid carcinoma, and advanced or recurrent differentiated thyroid carcinoma) to identify genes involved in the malignant transformation and dedifferentiation of thyroid cancer, and to analyze the characteristics of cell populations that constitute the tumor microenvironment."},"methods":{"ja":"scRNA-seq","en":"scRNA-seq"},"targets":{"ja":"甲状腺未分化がん 3症例、甲状腺乳頭がん 3症例","en":"undifferentiated thyroid carcinoma: 3 cases, papillary thyroid carcinoma: 3 cases"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"甲状腺未分化癌：3症例\n甲状腺乳頭癌：3症例\n（日本人）","en":"undifferentiated thyroid carcinoma: 3 cases\npapillary thyroid carcinoma: 3 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（scRNA-seq）","en":"NGS\n(scRNA-seq)"}},"releaseNote":{"ja":"甲状腺未分化がん3症例および甲状腺乳頭がん3症例の腫瘍組織より単離した細胞からRNAを抽出し、scRNA-seq解析を実施した。fastqデータならびに発現マトリクスデータ（h5）を提供する。","en":"RNA extracted from a single cell isolated from tumor tissues collected from 3 patients with undifferentiated thyroid carcinoma and 3 patients with papillary thyroid carcinoma were used for scRNA-seq analysis. Fastq data and expression matrix data (h5) are provided."},"dataProviders":[{"name":{"ja":"井口 研子","en":"Akiko Iguchi"},"organization":{"name":{"ja":"筑波大学 医学医療系 乳腺内分泌外科学分野","en":"Department of Breast and Endocrine Surgery, Institute of Medicine, University of Tsukuba"}}}],"researchProjects":[],"grants":[{"title":{"ja":"甲状腺未分化癌に対する新規免疫療法の開発のための研究","en":"Research for the development of novel immunotherapy for anaplastic thyroid carcinoma"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["JP20K08950"]}],"relatedPublications":[{"title":"Single-cell Transcriptome of Anaplastic Thyroid Cancer Reveals Immunosuppressive Tumor Microenvironment Remodeling","doi":"https://doi.org/10.1002/cam4.72261","datasets":["JGAD001086","E-GEAD-1308"]}],"datasets":["JGAD001086","E-GEAD-1308"],"controlledAccessUsers":[]}