{"id":"hum0585","version":1,"url":"https://humandbs.dbcls.jp/research/hum0585/v1","datePublished":"2026-08-28","versions":[{"version":1,"datePublished":"2026-08-28"}],"title":{"ja":"ヒト4倍体iPS細胞からの増殖期後心筋細胞の作製","en":"Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs"},"summary":{"aims":{"ja":"iPS細胞に心筋症に関わる遺伝子変異をゲノム編集により導入後、心筋細胞へと分化誘導した心筋症のモデルを作製し、心筋症の発症機序を探る。複数人から樹立されたiPS細胞を用いることで、遺伝的背景の影響も検討する。","en":"Using genome editing, we introduced mutations in genes associated with cardiomyopathy into iPS cells to model cardiomyopathy. We also tested iPS cells established from multiple individuals."},"methods":{"ja":"RNA-seq解析","en":"RNA-seq"},"targets":{"ja":"米国Gladstone研究所で樹立された、健常者由来iPS細胞（WTC11）、および心筋細胞に分化誘導した細胞、WTC11同士を融合させて樹立した4倍体iPS細胞、および当該4倍体iPS細胞を心筋細胞に分化誘導した細胞","en":"WTC11, an iPS cell line derived from a healthy individual, established at the Gladstone Institutes in its undifferentiated state and after differentiation into cardiomyocytes. The undifferentiated state and after differentiation into cardiomyocytes of tetraploid iPS cells established by fusing WTC11 cells."},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"未分化iPS細胞および分化誘導した心筋細胞：12検体\n（細胞株）","en":"undifferentiated iPS cells and differentiated cardiomyocytes: 12 samples\n(Cell-line)"},"typeOfData":{"ja":"NGS\n（RNA-seq）","en":"NGS\n(RNA-seq)"}},"releaseNote":{"ja":"健常者由来iPS細胞（WTC11）および分化誘導した心筋細胞、ならびに、 WTC11同士の細胞融合により樹立した4倍体iPS細胞および分化誘導した心筋細胞から抽出したRNAを用いたRNA-seq解析データをfastqファイル形式で提供する。","en":"RNAs extracted from undifferentiated iPS cells and differentiated cardiomyocytes of WTC11 and tetraploid iPS cells established by fusing WTC11 cells were used for the RNA sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"宮岡 佑一郎","en":"Yuichiro Miyaoka"},"organization":{"name":{"ja":"東京都医学総合研究所","en":"Tokyo Metropolitan Institute of Medical Science"}}}],"researchProjects":[{"name":{"ja":"再生医療プロジェクト","en":"Regenerative Medicine Project"},"url":{"ja":[{"url":"https://www.igakuken-regmed.com/","text":"https://www.igakuken-regmed.com/"}],"en":[{"url":"https://www.igakuken-regmed.com/home","text":"https://www.igakuken-regmed.com/home"}]}}],"grants":[{"title":{"ja":"細胞種により異なる倍数性の意義をiPS細胞モデルにより追究する","en":"Elucidating the Significance of Cell Type-Specific Ploidy Using iPSC Models"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["24K02028"]},{"title":{"ja":"マウスの交配のように自在なヒトiPS細胞間の遺伝子交換手法の開発","en":"Flexible gene exchange method between human iPS cell lines like mouse breeding"},"agency":{"ja":"科学研究費助成事業 挑戦的研究（萌芽）","en":"KAKENHI Grant-in-Aid for Challenging Research (Exploratory)"},"grantIds":["24K21954"]},{"title":{"ja":"心筋細胞の4倍体化を忠実に再現するiPS細胞心筋症モデルの開発","en":"iPSC-Derived Cardiomyocyte Model That Faithfully Recapitulates Cardiomyocyte Tetraploidization"},"agency":{"ja":"循環器病研究振興財団 バイエル循環器病研究助成","en":"Japan Cardiovascular Research Foundation, The Bayer Scholarship for Cardiovascular Research"},"grantIds":null},{"title":{"ja":"生体心臓を真に再現する4倍体iPS細胞由来心筋細胞モデルの確立","en":"Tetraploid iPSC-Derived Cardiomyocyte Model That Faithfully Recapitulates the In Vivo Heart"},"agency":{"ja":"先進医薬研究振興財団 循環医学分野 一般研究助成","en":"SENSHIN Medical Research Foundation"},"grantIds":null},{"title":{"ja":"4倍体化を再現する iPS 細胞由来心筋細胞による再生医療の革新","en":"Transforming Regenerative Medicine Using iPSC-Derived Cardiomyocytes That Recapitulate"},"agency":{"ja":"テルモ生命科学振興財団 再生医療研究助成","en":"TERUMO Life Science Foundation"},"grantIds":null}],"relatedPublications":[{"title":"Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs","doi":"https://doi.org/10.1038/s42003-026-10763-2","datasets":["DRA029128"]}],"datasets":["DRA029128"],"controlledAccessUsers":[]}