{"id":"hum0575","version":1,"url":"https://humandbs.dbcls.jp/research/hum0575/v1","datePublished":"2026-07-16","versions":[{"version":1,"datePublished":"2026-07-16"}],"title":{"ja":"腎癌における網羅的な遺伝子探索研究","en":"Comprehensive gene expression analysis in renal cell carcinoma"},"summary":{"aims":{"ja":"腫瘍発生や進展メカニズムの解明と治療薬の有効性および副作用に関連する遺伝子群の同定、ならびに、より正確で信頼度が高い診断法や治療標的の同定を目的とする。","en":"The goal is to elucidate the mechanisms of tumor initiation and progression, identify gene signatures associated with drug efficacy and adverse effects, and develop more accurate and reliable diagnostic methods and therapeutic targets."},"methods":{"ja":"手術摘出検体（凍結組織切片）より抽出したRNAを用いたRNA-seq解析","en":"RNA extracted from frozen tissue sections obtained from tumor and normal renal cortex specimens was used for RNA-seq analysis."},"targets":{"ja":"腎がんの診断で腎摘除術を受けた201症例","en":"201 patients diagnosed with renal cell carcinoma"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"腎癌：201症例\n（日本人）","en":"renal cell carcinoma: 201 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（RNA-seq）","en":"NGS\n(RNA-seq)"}},"releaseNote":{"ja":"腎がんの腫瘍組織および非腫瘍組織から抽出したRNAを用いたRNA-seq解析データをfastq、txtファイル形式で提供する。","en":"RNAs extracted from tumor and non-tumor tissues of renal cell carcinoma patients were used for the RNA sequencing analysis. Fastq and txt files are provided."},"dataProviders":[{"name":{"ja":"加藤 廉平","en":"Renpei Kato"},"organization":{"name":{"ja":"岩手医科大学 泌尿器科学講座","en":"Department of Urology, Iwate Medical University"}}}],"researchProjects":[{"name":{"ja":"腎癌における網羅的な遺伝子探索研究","en":"Comprehensive Genomic Exploration Study in Renal Cell Carcinoma"},"url":{"ja":null,"en":null}}],"grants":[{"title":{"ja":"生体内ネットワークの理解による難治性がん克服に向けた挑戦","en":"Challenge toward the Control of Intractable Cancer through Understanding of Molecular, Cellular, and Interorgan Networks"},"agency":{"ja":"JST ムーンショット型研究開発事業","en":"Moonshot R&D Program, Japan Science and Technology Agency (JST)"},"grantIds":["JPMJMS2022"]},{"title":{"ja":"がん抑制因子活性化を利用した治療耐性難治性乳がんに対する治療薬開発のための製剤化検討","en":"First-in-human phase I study of a tumor suppressor-activating therapeutic peptide"},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的がん医療実用化研究事業","en":"Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP25ck0106888"]}],"relatedPublications":[],"datasets":["JGAD001057"],"controlledAccessUsers":[]}