{"id":"hum0563","version":1,"url":"https://humandbs.dbcls.jp/research/hum0563/v1","datePublished":"2026-04-16","versions":[{"version":1,"datePublished":"2026-04-16"}],"title":{"ja":"「進行胃癌患者を対象とした Lenvatinib と Pembrolizumab 併用の第II相臨床試験」における患者免疫状態の解析","en":"\"Elucidation of Immune Status and Its Clinical Significance in Patients with Solid Tumors, Including Gastrointestinal Cancers\": A Phase II Clinical Trial of Lenvatinib Plus Pembrolizumab in Patients with Advanced Gastric Cancer"},"summary":{"aims":{"ja":"体細胞遺伝子における変異負荷および免疫関連遺伝子発現を解析し、抗腫瘍免疫応答の詳細な機序を解明する","en":"Analysis of somatic mutational burden and immune-related gene expression to elucidate the detailed mechanisms of anti-tumor immune responses."},"methods":{"ja":"whole exome sequencingおよびRNA sequencing","en":"Whole exome sequencing, RNA sequencing"},"targets":{"ja":"胃がん 11症例","en":"gastric cancer"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定\n発現","en":"Sequencing, Expression profiling"},"targets":{"ja":"胃癌：11症例\n（日本人）","en":"gastric cancer: 11 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome、RNA-seq）","en":"NGS\n(Exome, RNA-seq)"}},"releaseNote":{"ja":"胃がん11症例の腫瘍組織および非腫瘍組織より抽出したDNA/RNAを用いたwhole exome sequencing、ならびにRNA sequencing解析データをfastqファイルにて提供する。","en":"DNA/RNA extracted from tumor and non-tumor tissues from gastric cancer patients were used for the whole exome sequencing and RNA sequencing analyses. Fastq files are provided."},"dataProviders":[{"name":{"ja":"小山 正平","en":"Shohei Koyama"},"organization":{"name":{"ja":"国立がん研究センター 免疫ゲノム解析部門","en":"Department of Immuno genomic medicine, National Cancer Center"}}}],"researchProjects":[{"name":{"ja":"胃癌におけるマクロファージのリプログラミングに関する検討","en":"Macrophage Reprogramming in Gastric Cancer"},"url":{"ja":null,"en":null}}],"grants":[{"title":{"ja":"慢性炎症の制御によるがん発症ゼロ社会の実現","en":"Actualization of a cancer-free society through regulation of chronic inflammation"},"agency":{"ja":"日本医療研究開発機構（AMED） ムーンショット型研究開発等事業","en":"Moonshot Research and Development Program, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP22zf0127009"]},{"title":{"ja":"プライミング相の免疫調節による治療効果持続型の新規免疫療法戦略の開発","en":"Development of a novel immunotherapeutic strategy with sustained therapeutic effect by modulating the priming phase"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代がん医療加速化研究事業","en":"Promotion of Cancer Research and Therapeutic Evolution, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP23ama221329"]},{"title":{"ja":"がん細胞上の免疫抑制分子を標的とした分子標的-免疫一体型治療の樹立","en":"Establishment of molecular target-immune integrated therapy targeting immunosuppressive molecules on cancer cells."},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的がん医療実用化研究事業","en":"Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP23ck0106796"]},{"title":{"ja":"先進的免疫ゲノム解析確立に向けた検体バンキングと網羅解析基盤の樹立","en":"Establishment of specimen banking and comprehensive analysis platforms for advanced immunogenomic profiling"},"agency":{"ja":"国立がん研究センター研究開発費","en":"National Cancer Center Research and Development Fund"},"grantIds":["2024-A-03"]}],"relatedPublications":[{"title":"Lenvatinib combined with PD-1 blockade therapy benefits gastric cancers through immunosuppressive macrophage modulation","doi":"https://doi.org/10.1158/2326-6066.cir-25-0982","datasets":["JGAD001038"]}],"datasets":["JGAD001038"],"controlledAccessUsers":[]}