{"id":"hum0556","version":1,"url":"https://humandbs.dbcls.jp/research/hum0556/v1","datePublished":"2026-06-23","versions":[{"version":1,"datePublished":"2026-06-23"}],"title":{"ja":"肺癌の遺伝子発現解析の生物学的特性ならびに診断・治療におけるバイオマーカーの研究","en":"Research on the biological characteristics of gene expression profiles and biomarkers for diagnosis and treatment in lung cancer"},"summary":{"aims":{"ja":"胸部腫瘍組織および正常組織の解析を通してがんの病態を把握することにより、がんの予防・診断・治療法の確立、さらには新規治療法の開発を目指す","en":"By analyzing thoracic tumor specimens and normal tissues, this study aims to elucidate the pathophysiology of cancer, thereby contributing to cancer prevention, the establishment of diagnostic and therapeutic methods, and the development of novel treatments."},"methods":{"ja":"ChIP-seq解析","en":"ChIP-seq"},"targets":{"ja":"肺がん17症例由来腫瘍組織","en":"Tumor samples from 17 patients with lung cancer"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"ヒストン修飾","en":"Histone modification profiling"},"targets":{"ja":"肺癌：17症例\n（日本人）","en":"lung cancer: 17 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（ChIP-seq）","en":"NGS\n(ChIP-seq)"}},"releaseNote":{"ja":"肺がん17症例のFFPE腫瘍組織24検体から抽出したDNAを用いたChIP-seq解析結果をfastqファイルおよびbedファイルにて提供する。","en":"DNAs extracted from 24 FFPE tumor samples from 17 patients with lung cancer were used for the ChIP-seq analysis. Fastq and bed files are provided."},"dataProviders":[{"name":{"ja":"佐藤 崇","en":"Takashi Sato"},"organization":{"name":{"ja":"北里大学医学部 呼吸器内科学","en":"Department of Respiratory Medicine, Kitasato University School of Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"エピゲノム解析を用いた各種肺癌の分化プログラムの探索","en":"Exploration of differentiation programs in lung cancers using epigenomic profiling"},"agency":{"ja":"科学研究費助成事業 若手研究","en":"KAKENHI Grant-in-Aid for Early-Career Scientists"},"grantIds":["20K17192"]},{"title":{"ja":"各種肺がんの分化プログラムにおけるマスター制御因子の役割","en":"Exploring the roles of master regulators in differentiation programs of various lung cancers"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["23K07609"]},{"title":{"ja":"肺神経内分泌腫瘍におけるMYCファミリー癌遺伝子に関連したバイオマーカー探索","en":"Search for MYC-related biomarkers for lung neuroendocrine neoplasms"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["22K08288"]},{"title":{"ja":"肺がんにおける分化プログラムの不均一性と可塑性の解明","en":"Heterogeneity and plasticity of differentiation programs in lung cancer"},"agency":{"ja":"公益財団法人 MSD生命科学財団 研究助成 - がん領域","en":"MSD Life Science Foundation, Public Interest Incorporated Foundation"},"grantIds":null},{"title":{"ja":"肺がんのフェノタイプを規定する分化プログラムの不均一性・可塑性の解明","en":"Deciphering the Heterogeneity and Plasticity of Differentiation Programs that Define Lung Cancer Phenotypes"},"agency":{"ja":"公益財団法人 武田科学振興財団 医学系研究助成","en":"Medical Research Grant, Takeda Science Foundation"},"grantIds":null},{"title":{"ja":"肺がんの進展・適応過程における可塑性に関する研究","en":"Investigating Plasticity in Lung Cancer Progression and Adaptation"},"agency":{"ja":"公益財団法人 内藤記念科学振興財団 内藤記念科学奨励金・研究助成","en":"The Naito Foundation"},"grantIds":null}],"relatedPublications":[{"title":"Epigenomic profiling of neuroendocrine lung cancers identifies a classical-neuroendocrine ASCL1/NKX2-1 subtype and a SOX11-associated differentiation axis linked to reduced immunogenicity","doi":"https://doi.org/10.1016/j.lungcan.2026.109464","datasets":["JGAD001047"]}],"datasets":["JGAD001047"],"controlledAccessUsers":[]}