{"id":"hum0551","version":1,"url":"https://humandbs.dbcls.jp/research/hum0551/v1","datePublished":"2026-02-05","versions":[{"version":1,"datePublished":"2026-02-05"}],"title":{"ja":"疾患コホートと一般コホート研究の組み合わせによるアレルギー疾患発症ならびにアレルゲン免疫応答を予測するためのゲノム基盤構築","en":"Development of a prediction method for allergic diseases and allergen responsiveness using patients cohorts and general population cohorts"},"summary":{"aims":{"ja":"アレルギー疾患に対する効果的な予防法、治療法の開発を目指したゲノム基盤の構築","en":"Establishing a genomic foundation aimed at developing effective prevention and treatment methods for allergic diseases"},"methods":{"ja":"SNPアレイ解析により遺伝子型決定を行い、ゲノムワイド関連解析を行った。また、EAGLE Rhinitis ConsortiumよりGWAS統計データの提供を受け、メタ解析を行った。","en":"Genotyping was performed using SNP arrays, followed by a genome-wide association study. For the 25,032 individuals from European populations, meta-analysis was performed using statistical values provided by the EAGLE Rhinitis Consortium."},"targets":{"ja":"日本人一般集団43,834名（症例20,492名、対照23,342名）のアレルギー感作GWASメタ解析\n日本人一般集団43,834名（症例20,492名、対照23,342名）とヨーロッパ人一般集団25,032名（症例8,246名、対照16,786名）のアレルギー感作GWASメタ解析\n日本人一般集団21,932名（症例4,923名、対照17,009名）の多感作GWASのメタ解析","en":"Meta-analysis of allergic sensitization GWAS in the Japanese general population: Case 20,492, Control 23,342\nMeta-analysis of allergic sensitization GWAS in the Japanese general population and European general population: Case 28,738, Control 40,128\nMeta-analysis of polysensitization GWAS in the Japanese general population: Case 4,923, Control 17,009"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"ゲノムワイド\n関連","en":"Genome-wide association study"},"targets":{"ja":"日本人一般集団43,834名（アレルギー感作20,492名、対照23,342名）\n（日本人）\nヨーロッパ人一般集団25,032名（アレルギー感作8,246名、対照16,786名）\n（ヨーロッパ人）","en":"Japanese general population: allergic sensitization case 20,492, control 23,342\n(Japanese)\nEuropean general population: allergic sensitization case 8,246, control 16,786\n(European)"},"typeOfData":{"ja":"SNP-chip","en":"SNP-chip"}},"releaseNote":{"ja":"日本人一般集団43,834名（症例20,492名、対照23,342名）のアレルギー感作GWASメタ解析、日本人一般集団43,834名（症例20,492名、対照23,342名）とヨーロッパ人一般集団25,032名（症例8,246名、対象16,786名）のアレルギー感作GWASメタ解析、および、日本人一般集団21,932名（症例4,923名、対照17,009名）の多感作GWASのメタ解析結果をtxtファイルにて提供する。","en":"DNA was extracted from peripheral blood cells, followed by genotyping and subsequent association analysis. For the 25,032 individuals from European populations, meta-analysis was performed using statistical values provided by the EAGLE Rhinitis Consortium.\n- Meta-analysis of allergic sensitization GWAS in the Japanese general population: Case 20,492, Control 23,342\n- Meta-analysis of allergic sensitization GWAS in the Japanese general population and European general population: Case 28,738, Control 40,128\n- Meta-analysis of polysensitization GWAS in the Japanese general population: Case 4,923, Control 17,009\nGWAS summary statistics are provided as txt files."},"dataProviders":[{"name":{"ja":"野口 恵美子","en":"Emiko Noguchi"},"organization":{"name":{"ja":"筑波大学医学医療系 遺伝医学","en":"Department of Medical Genetics, Faculty of Medicine, University of Tsukuba"}}}],"researchProjects":[],"grants":[{"title":{"ja":"HLAの多様性がアレルギーに与える影響をビッグデータ解析により解明する","en":"Elucidating the Impact of HLA Diversity on Allergies Through Big Data Analysis"},"agency":{"ja":"科学研究費助成事業 特別研究員奨励費","en":"KAKENHI Grant-in-Aid for JSPS Fellows"},"grantIds":["21J11802"]},{"title":{"ja":"ゲノムデータに基づくアレルギー疾患発症予測法の開発","en":"Development of a Genome-Based Prediction Method for the Onset of Allergic Diseases"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["23H03143"]},{"title":{"ja":"疾患コホートと一般コホート研究の組み合わせによるアレルギー疾患発症ならびにアレルゲン免疫応答を予測するためのゲノム基盤構築","en":"Development of a prediction method for allergic diseases and allergen responsiveness using patients cohorts and general population cohorts"},"agency":{"ja":"日本医療研究開発機構（AMED）免疫アレルギー疾患実用化研究事業","en":"Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP20ek0410076"]},{"title":{"ja":"大規模ゲノム解析に必要な計算基盤構築とゲノム解析に関する研究","en":"Development of computational infrastructure required for large-scale genome analysis and research on genome analysis"},"agency":{"ja":"日本医療研究開発機構（AMED） ゲノム医療実現バイオバンク利活用プログラム（B-Cure）","en":"Biobank - Construction and Utilization biobank for genomic medicine REalization (B-Cure), Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP21tm0424601"]}],"relatedPublications":[{"title":"A genome-wide meta-analysis reveals shared and population-specific variants for allergic sensitization","doi":"https://doi.org/10.1016/j.jaci.2024.11.033","datasets":["NHA000206"]}],"datasets":["NHA000206"],"controlledAccessUsers":[]}