{"id":"hum0548","version":1,"url":"https://humandbs.dbcls.jp/research/hum0548/v1","datePublished":"2026-02-04","versions":[{"version":1,"datePublished":"2026-02-04"}],"title":{"ja":"TMDUバイオリソースセンター保管のがん検体を用いた網羅的がん関連遺伝子エキソーム解析とその情報解析に基づく個別化医療に資する新たな診断、治療、予防法の開発","en":"Development of New Diagnostics, Therapeutics, and Prevention Methods for Personalized Medicine Based on Comprehensive Cancer-Related Gene Exome Analysis and Information Analysis Using Cancer Specimens Stored in TMDU Biobank."},"summary":{"aims":{"ja":"網羅的遺伝子解析と詳細な臨床情報の統合により、がん個別化医療に資する新たな診断法・治療法・予防法の開発を推進するため、東京医科歯科大学疾患バイオリソースセンターが収集・保管する約2000例のがん組織試料と臨床情報を基盤とし、440種類のがん関連遺伝子と31種類のがん関連融合遺伝子を対象とするACTOnco®+がん遺伝子パネル解析を行う。","en":"This study used about 2,000 cancer tissue samples and clinical data from Bioresource Research Center, Tokyo Medical and Dental University. Using the ACTOnco®+ panel targeting 440 genes, genomic analysis were integrated with clinical information to develop new diagnostics, therapies, and preventive strategies for personalized cancer medicine."},"methods":{"ja":"ACTOnco Comprehensive 440-Gene Cancer Panel（Target capture sequencing解析、RNA-seq解析）","en":"Target capture sequencing, RNA sequencing"},"targets":{"ja":"東京医科歯科大学疾患バイオリソースセンターに登録された成人固形がん1,996症例","en":"1,996 adult solid tumor patients who provided broad consent to the Biobank Project of Tokyo Medical and Dental University."},"url":{"ja":[{"url":"https://www.tmd.ac.jp/cmn/brc/news/20200212/index.html","text":"https://www.tmd.ac.jp/cmn/brc/news/20200212/index.html"}],"en":null}},"listingSummary":{"methods":{"ja":"配列決定\n発現","en":"Sequencing and expression profiling"},"targets":{"ja":"成人固形癌：1,996症例\n（日本人）","en":"adult solid tumor: 1,996 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Target Capture、RNA-seq）","en":"NGS\n(Target Capture, RNA-seq)"}},"releaseNote":{"ja":"成人固形がん1,996症例から得られたFFPE検体の腫瘍組織から抽出したDNA/RNAを用いたACTOnco Comprehensive 440-Gene Cancer Panel解析によるサマリデータ（平均腫瘍遺伝子変異量（Tumor Mutational Burden：TMB）、アリルカウント、アリル頻度、平均深度など）ならびに医療データ（ICD10疾患分類コード、症例数など）をxlsxファイルにて提供する。","en":"DNA/RNA extracted from tumor tissues obtained from 1,996 adult solid tumor patients were used for ACTOnco Comprehensive 440-Gene Cancer Panel analyses. Summary data are provided (xlsx file)."},"dataProviders":[{"name":{"ja":"田中 敏博","en":"Toshihiro Tanaka"},"organization":{"name":{"ja":"東京科学大学 BRC・疾患多様性研究部門","en":"Department of Human Genetics and Disease Diversity, Institute of Science Tokyo"}}}],"researchProjects":[],"grants":[],"relatedPublications":[{"title":"Genomic landscape of oral squamous cell carcinoma highlights prognostic significance of NOTCH1 mutations and subsite-specific differences","doi":"https://doi.org/10.21203/rs.3.rs-8623006/v1","datasets":["JGAD001006"]}],"datasets":["JGAD001006"],"controlledAccessUsers":[]}