{"id":"hum0536","version":1,"url":"https://humandbs.dbcls.jp/research/hum0536/v1","datePublished":"2026-04-08","versions":[{"version":1,"datePublished":"2026-04-08"}],"title":{"ja":"悪性胸膜中皮腫と関連疾患におけるゲノミクス解析と治療標的の探索","en":"Genomic Analysis and Exploration of Therapeutic Targets in Malignant Pleural Mesothelioma and Related Diseases"},"summary":{"aims":{"ja":"悪性胸膜中皮腫は、肺や胸郭を裏打ちする胸膜から発生する予後不良の悪性腫瘍であり、その分子メカニズムの解明は診断・治療法の確立に重要である。本研究では、腫瘍および非腫瘍組織を対象にゲノム・遺伝子発現解析を行い、腫瘍の発生や進展に関与する分子経路を探索する。得られた候補分子については、遺伝子発現、局在、動態、細胞間相互作用などを解析し、臨床病理学的指標との関連性を検討する。さらに、腫瘍組織を保存し、マウスモデルや細胞培養系での機能解析に供する。","en":"Malignant pleural mesothelioma is an aggressive pleural tumor with poor prognosis. Understanding the molecular mechanisms underlying its development and progression is essential for improving diagnosis and treatment. This study aims to identify clinically relevant molecular pathways through genomic and transcriptome analyses of tumor and non-tumor pleural tissues. Candidate genes associated with tumor initiation and progression will be analyzed in terms of gene expression, localization, dynamics, and cell-to-cell interactions. Their correlation with clinicopathological parameters will also be investigated. Tumor tissues will be preserved by cryopreservation or transplantation into immunodeficient mice to enable further studies using in vivo models or in vitro cell culture systems."},"methods":{"ja":"全ゲノム解析、single-cell RNA-seq解析、ATAC-seq解析","en":"WGS, single-cell RNA-seq, ATAC-seq"},"targets":{"ja":"胸膜中皮腫 1症例","en":"One pleural mesothelioma patient"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列\n発現\nクロマチン構造","en":"Sequencing, expression profiling, and chromatin structure analysis"},"targets":{"ja":"胸膜中皮腫：1症例\n（日本人）","en":"Pleural mesothelioma: 1 case\n(Japanese)"},"typeOfData":{"ja":"NGS\n（WGS、scRNA-seq、ATAC-seq）","en":"NGS\n(WGS, scRNA-seq, ATAC-seq)"}},"releaseNote":{"ja":"胸膜中皮腫1症例の腫瘍組織、症例由来のXenograft腫瘍モデル検体、および症例由来の細胞株より抽出したDNA/RNAを対象としたWGS解析、scRNA-seq解析、および、ATAC-seq解析の結果をfastqファイルにて提供する。","en":"- DNA/RNA extracted from tumor specimens, patient-derived xenograft (PDX) tumor model specimen, and patient-derived cell line of one patient with pleural mesothelioma were used for WGS, scRNA-seq and ATAC-seq analyses. Fastq files are provided."},"dataProviders":[{"name":{"ja":"石川 俊平","en":"Shumpei Ishikawa"},"organization":{"name":{"ja":"東京大学大学院医学系研究科 衛生学教室","en":"Department of Preventive Medicine, Graduate School of Medicine, The University of Tokyo"}}}],"researchProjects":[],"grants":[{"title":{"ja":"組織空間とゲノム情報の定量的統合による胃癌多様性の新しい定義","en":"A New Definition of Heterogeneity in Gastric Cancer through Quantitative Integration of Spatial Tissue and Genomic Information"},"agency":{"ja":"科学研究費助成事業 基盤研究（S）","en":"KAKENHI Grant-in-Aid for Scientific Research (S)"},"grantIds":["22H04990"]},{"title":{"ja":"難治がんの治療経過に伴うゲノム病理情報のトラジェクトリ","en":"Trajectory Analysis of Genomic and Pathological Information during the Treatment Course of Refractory Cancers"},"agency":{"ja":"日本医療研究開発機構（AMED）革新的がん医療実用化研究事業","en":"Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP24ck0106904"]},{"title":{"ja":"びまん型胃癌における新たな好中球-がん相互作用の解明","en":"Elucidation of a Novel Neutrophil-Tumor Interaction in Diffuse-Type Gastric Cancer"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["23K27436"]},{"title":{"ja":"悪性胸膜中皮腫における腫瘍間質相互作用の機序解明と治療標的の同定","en":"Mechanistic Dissection of Tumor-Stromal Interactions and Identification of Therapeutic Targets in Malignant Pleural Mesothelioma"},"agency":{"ja":"科学研究費助成事業 特別研究員奨励費","en":"KAKENHI Grant-in-Aid for JSPS Fellows"},"grantIds":["23KJ0836"]}],"relatedPublications":[{"title":"Cooperative Response Loops Enhanced by Histamine Signaling during Tumor-Neutrophil Crosstalk in Pleural Mesothelioma","doi":"https://doi.org/10.1016/j.celrep.2026.117361","datasets":["JGAD001002"]}],"datasets":["JGAD001002"],"controlledAccessUsers":[]}