{"id":"hum0535","version":1,"url":"https://humandbs.dbcls.jp/research/hum0535/v1","datePublished":"2025-10-20","versions":[{"version":1,"datePublished":"2025-10-20"}],"title":{"ja":"皮膚疾患が皮膚構成細胞、血液、他臓器の細胞の変化に与える影響に関する探索的研究","en":"A study on the impact of skin diseases on cellular alterations in skin component cells, blood, and other organ cells"},"summary":{"aims":{"ja":"皮膚・血液・関連臓器由来細胞から抽出したDNAおよびRNAを網羅的に解析し、皮膚疾患に伴う分子・細胞レベルの変化を明らかにすることで、病態機序の解明と新規治療法の開発に資する基盤知見を得ること。","en":"To perform comprehensive genomic and transcriptomic analyses of DNA and RNA obtained from the skin, blood, and related organs of patients with dermatological diseases, in order to elucidate disease mechanisms and provide a basis for developing novel therapeutic strategies."},"methods":{"ja":"ATAC-seq","en":"ATAC-seq"},"targets":{"ja":"乾癬6症例の病変皮膚、臨床的治癒皮膚、健常皮膚、それぞれから分離した表皮ケラチノサイト","en":"Epidermal keratinocytes from psoriatic lesions, clinically healed skin of the same patients, and healthy control skin"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"クロマチン構造","en":"Chromatin structure analysis"},"targets":{"ja":"乾癬：6症例\n（日本人）","en":"Psoriasis: 6 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（ATAC-seq）","en":"NGS\n(ATAC-seq)"}},"releaseNote":{"ja":"乾癬6症例の病変皮膚、臨床的治癒皮膚、健常皮膚から分離した表皮ケラチノサイトより抽出したDNAを対象としたATAC-seq解析データをbamファイルにて提供する。","en":"DNA extracted from psoriatic, clinically healed, and healthy control skin of psoriasis patients were used for ATAC-seq analysis. Bam files are provided."},"dataProviders":[{"name":{"ja":"柴田 彩","en":"Sayaka Shibata"},"organization":{"name":{"ja":"東京大学 大学院医学系研究科","en":"Department of Dermatology, Graduate School of Medicine, The University of Tokyo"}}}],"researchProjects":[],"grants":[{"title":{"ja":"レジリエンス破綻による炎症性皮膚疾患の慢性化機序の解明と治療戦略","en":"Mechanisms for Chronic Inflammation of Skin Diseases Due to Resilience Failure and Treatment Strategies"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["24K11447"]},{"title":{"ja":"ストレスメモリーによる炎症の慢性化と拡大のメカニズム解明とストレスセンシングの可視化","en":"Mechanistic Elucidation of Stress Memory-Driven Chronic Inflammation and Visualization of Stress Sensing"},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的先端研究開発支援事業 ソロタイプ（PRIME）","en":"Precursory Research for Innovative Medical care (PRIME), Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP24gm6910016"]},{"title":{"ja":"DNA環境およびスーパーエンハンサーを介した乾癬病態制御機構の解明","en":"Elucidation of the Regulatory Mechanisms of Psoriatic Pathogenesis Mediated by DNA Environment and Super-Enhancers"},"agency":{"ja":"一般財団法人リディアオリリー記念ピアス皮膚科学振興財団","en":"Lydia O'Leary Memorial Pias Dermatological Foundation"},"grantIds":null}],"relatedPublications":[],"datasets":["JGAD000986"],"controlledAccessUsers":[]}