{"id":"hum0527","version":1,"url":"https://humandbs.dbcls.jp/research/hum0527/v1","datePublished":"2025-08-05","versions":[{"version":1,"datePublished":"2025-08-05"}],"title":{"ja":"子宮頚部・腟部発生リンパ腫の遺伝子変異の検索","en":"Genetic mutation profiling of lymphomas arising in the uterine cervix and vagina"},"summary":{"aims":{"ja":"子宮頸部・膣部のfollicle center lymphoma（濾胞性リンパ腫）は、これまでの報告数が20例に満たない稀少なリンパ腫である。子宮頸部・膣部の濾胞性リンパ腫の遺伝学的知見は少ないため、全エクソームシークエンス解析あるいは遺伝子パネル解析を実施することで、本腫瘍に関連する遺伝子変異を検出する。","en":"Follicle center lymphoma (FCL) of the lower female genital tract (LFGT) is a rare lymphoma, with fewer than 20 cases reported to date. Since the genetic features of FCL of the LFGT have not been well characterized, we aimed to identify genetic alterations in this tumor through whole-exome sequencing and targeted gene panel analyses."},"methods":{"ja":"Whole exome sequencing解析","en":"Whole exome sequencing analysis"},"targets":{"ja":"子宮頸部・膣部の濾胞性リンパ腫：1症例","en":"FCL of the LFGT: 1 case"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"子宮頸部・膣部の濾胞性リンパ腫：1症例\n（日本人）","en":"Follicle center lymphoma of the lower female genital tract: 1 case\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）","en":"NGS\n(Exome)"}},"releaseNote":{"ja":"子宮頸部・膣部の濾胞性リンパ腫 1症例の子宮頸部腫瘤凍結検体の腫瘍組織から抽出したDNAを用いたwhole exome sequencing解析データをfastq、vcfファイルにて提供する。","en":"DNAs extracted from a frozen tissue sample obtained from a surgically resected uterine cervical tumor of follicle center lymphoma of the lower female genital tract were used for the whole exome sequencing analysis. Fastq and vcf files are provided."},"dataProviders":[{"name":{"ja":"北岡 匠","en":"Takumi Kitaoka"},"organization":{"name":{"ja":"米沢市立病院 病理診断科","en":"Department of Pathology, Yonezawa City Hospital"}}}],"researchProjects":[],"grants":[{"title":{"ja":"IgG4関連唾液腺炎に特異的な線維化誘導の分子メカニズムの解明","en":"The specific mechanism of fibrosis in IgG4-related sialadenitis"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["22K09661"]}],"relatedPublications":[],"datasets":["JGAD000965"],"controlledAccessUsers":[]}