{"id":"hum0524","version":1,"url":"https://humandbs.dbcls.jp/research/hum0524/v1","datePublished":"2025-11-11","versions":[{"version":1,"datePublished":"2025-11-11"}],"title":{"ja":"AYA（Adolescence and Young Adult）世代がんの治療標的の同定を目指した体細胞ゲノム解析研究","en":"Somatic genome analysis research aimed at the identification of treatment targets for young-onset cancer"},"summary":{"aims":{"ja":"NCCバイオバンク試料を用いてゲノム解析を行うことで、AYA世代がん及び希少がんの体細胞遺伝子異常プロファイルを明らかにし、治療標的分子の探索を行う。","en":"By conducting genome analysis using NCC Biobank samples, we will clarify the somatic alterations of young-onset and rare cancers and explore therapeutic target molecules."},"methods":{"ja":"全エクソームシーケンス解析、ターゲットシーケンス解析、RNAシーケンス解析","en":"Whole exome sequencing, Target capture sequencing, RNA sequencing"},"targets":{"ja":"卵巣がん 51症例（AYA世代 6症例、非AYA世代 45症例）","en":"Ovarian cancer 51 patients (AYA Generation 6 patients, non-AYA Generation 45 patients)"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定\n発現","en":"Sequencing and expression profiling"},"targets":{"ja":"卵巣癌：51症例\n（日本人）","en":"Ovarian cancer: 51 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome、Target Capture、RNA-seq）","en":"NGS\n(Exome, Target Capture, RNA-seq)"}},"releaseNote":{"ja":"卵巣がん51症例（AYA世代 6症例、非AYA世代 45症例）の腫瘍組織から抽出したDNA/RNAを用いたWES解析データ、Target Capture Sequencing解析データ（NCC oncopanel）、ならびに、RNA-seq解析データをfastqファイルにて提供する。","en":"DNAs/RNAs were extracted from tumor tissues of 51 ovarian cancer patients (6 AYA generations and 45 non-AYA generations). Whole exome sequencing, target capture sequencing and RNA sequencing analyses were performed. Fastq files are provided."},"dataProviders":[{"name":{"ja":"河野 隆志","en":"Takashi Kohno"},"organization":{"name":{"ja":"国立がん研究センター研究所 ゲノム生物学研究分野","en":"Research Institute Division of Genome Biology, National Cancer Center"}}}],"researchProjects":[{"name":{"ja":"若年婦人科腫瘍","en":"Gynecologic oncology in young women"},"url":{"ja":null,"en":null}}],"grants":[{"title":{"ja":"FIOCのコアファシリティ機能とバイオリソースの進化・結合によるTR・創薬研究推進","en":"Advancing Therapeutic Research and Drug Discovery through the Evolution and Integration of FIOC Core Facility Functions and Biological Resources"},"agency":{"ja":"国立がん研究センター研究開発費","en":"National Cancer Center Research and Development Fund"},"grantIds":["2020-J-2"]}],"relatedPublications":[{"title":"Metabolomic and transcriptomic analyses identify metabolic alterations and immune suppression in ovarian cancer","doi":"https://doi.org/10.1038/s41598-026-38014-8","datasets":["JGAD000973"]}],"datasets":["JGAD000973"],"controlledAccessUsers":[]}