{"id":"hum0522","version":1,"url":"https://humandbs.dbcls.jp/research/hum0522/v1","datePublished":"2025-06-26","versions":[{"version":1,"datePublished":"2025-06-26"}],"title":{"ja":"制御性T細胞特異的エピゲノム誘導による免疫制御の研究","en":"Immune regulation by cotrolling regulatory T cell-specific epigenome"},"summary":{"aims":{"ja":"免疫チェックポイント阻害薬（Immune Checkpoint Inhibitor：ICI）治療後のICI結合疲弊前駆T細胞の動態の検討ならびに自己免疫疾患における免疫担当細胞の解析","en":"To address the dynamics of immune checkpoint inhibitor (ICI)-bound progenitor-exhausted T cells after ICI treatment and analysis of immune cells in autoimmune diseases"},"methods":{"ja":"scRNA-seq、TCR-seq、CITE-seq","en":"scRNA-seq, TCR-seq, CITE-seq"},"targets":{"ja":"食道胃接合部がん2症例、胃がん3症例","en":"Esophagogastric junction cancer 2 cases, gastric cancer 3 cases"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"食道胃接合部癌：2症例\n胃癌：3症例\n（日本人）","en":"2 esophagogastric junction cancer\n3 Ggastric cancer\n(Japanese)"},"typeOfData":{"ja":"NGS\n（scRNA-seq、TCR-seq、CITE-seq）","en":"NGS\n(scRNA-seq, TCR-seq, CITE-seq)"}},"releaseNote":{"ja":"食道胃接合部がん2症例、ならびに胃がん3症例の末梢血、腫瘍、転移リンパ節、非転移リンパ節、転移性肝がんから分離したT細胞より抽出したRNAを用いたscRNA-seq、TCR-seq、CITE-seq解析データをfastq ファイル形式にて提供する。","en":"RNAs extracted from the blood, tumor, metastatic lymph nod, non-metastatic lymph node, and metastatic liver cancer samples from 2 esophagogastric junction cancer and 3 gastric cancer patients were used for single-cell RNA-seq, TCR-seq and CITE-seq analyses. Fastq files are provided."},"dataProviders":[{"name":{"ja":"西塔 拓郎","en":"Takuro Saito"},"organization":{"name":{"ja":"大阪大学大学大学院医学系研究科 消化器外科","en":"Department of gastroenterological surgery, Osaka University"}}}],"researchProjects":[],"grants":[{"title":{"ja":"胃癌リンパ節の免疫活性化とチェックポイント阻害薬がリンパ節に与える影響の検討","en":"Immune status of lymph nodes in gastric cancer and the effect of checkpoint inhibitors on lymph nodes"},"agency":{"ja":"科学研究費助成事業 若手研究","en":"KAKENHI Grant-in-Aid for Early-Career Scientists"},"grantIds":["23K15472"]},{"title":{"ja":"ヒト胃癌リンパ節における免疫抑制機構の解明","en":"The analysis for the suppressive mechanism of antitumor immunity in lymph nods of gastric cancer"},"agency":{"ja":"科学研究費助成事業 若手研究","en":"KAKENHI Grant-in-Aid for Early-Career Scientists"},"grantIds":["20K17685"]},{"title":{"ja":"ニボルマブ結合T細胞検出法を用いた免疫チェックポイント阻害薬の治療効果機序の解明","en":"Elucidating the Mechanism of effect of Immune Checkpoint Inhibitors Through Detection of Nivolumab-Bound T Cells"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["23K08194"]},{"title":{"ja":"胃癌所属リンパ節の空間的位置に注目した抗腫瘍リンパ球活性化・抑制化機構の解明","en":"Mechanistic Insights into Antitumor Lymphocyte Regulation in Gastric Cancer by Spatial Mapping of Lymph Nodes"},"agency":{"ja":"公益財団法人 武田科学振興財団 医学系研究助成 がん領域（基礎）","en":"Medical research grant, Takeda Science Foundation"},"grantIds":null},{"title":{"ja":null,"en":null},"agency":{"ja":"公益財団法人 伊藤忠兵衛基金 医療研究助成","en":"Medical research grant, Chubei Itoh Foundation"},"grantIds":null}],"relatedPublications":[{"title":"PD-1 antibody-bound progenitor-exhausted CD8+ T cells in lymph nodes boost PD-1-blockade anti-tumor immunity in gastrointestinal cancer","doi":"https://doi.org/10.1038/s41467-026-70751-2","datasets":["JGAD000853"]}],"datasets":["JGAD000853"],"controlledAccessUsers":[]}