{"id":"hum0519","version":1,"url":"https://humandbs.dbcls.jp/research/hum0519/v1","datePublished":"2026-02-10","versions":[{"version":1,"datePublished":"2026-02-10"}],"title":{"ja":"自己免疫疾患の抗原特異性の詳細解析","en":"Detailed analysis of antigen specificity in autoimmune diseases"},"summary":{"aims":{"ja":"自己免疫疾患においては、自己成分に対して免疫細胞が反応することが知られている。本研究では、通常は存在しない、もしくは機能的に抑制・無力化されていると考えられる自己反応性免疫担当細胞を同定し、詳細に解析することにより、自己免疫疾患の病態解明、ひいては医学の発展に寄与する事を目的とする。","en":"In patients with autoimmune diseases, it is known that immune cells react against components of their own body. By identifying and characterizing immune cells that respond to self-antigens - components that should normally be absent or rendered immunologically inert - we aim to elucidate the mechanisms underlying autoimmune pathology and contribute to the advancement of medical science."},"methods":{"ja":"シングルセルRNAシークエンス/TCRレパトア解析","en":"Single cell RNA sequencing/TCR repertoire analyses"},"targets":{"ja":"抗SSA抗体陽性のシェーグレン症候群由来の唾液腺組織","en":"Labial salivary gland tissue obtained from patients with Sjögren's syndrome who tested positive for anti-SSA antibodies"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"シェーグレン症候群：8症例\n（日本人）","en":"8 Sjögren's syndrome\n(Japanese)"},"typeOfData":{"ja":"NGS\n（scRNA-seq/TCRレパトア解析）","en":"NGS\n(scRNA-seq/TCR repetoire)"}},"releaseNote":{"ja":"抗SSA抗体陽性のシェーグレン症候群8症例の唾液腺組織から抽出したRNAを用いたscRNA-seq/TCRレパトア解析データをbam、csv形式にて提供する。","en":"RNAs extracted from labial salivary glands from 8 patients with Sjögren's syndrome were used for the single-cell RNA sequencing/TCR repertoire analyses. Bam and csv files are provided."},"dataProviders":[{"name":{"ja":"竹下 勝","en":"Masaru Takeshita"},"organization":{"name":{"ja":"慶應義塾大学医学部 リウマチ・膠原病内科","en":"Division of Rheumatology, Keio University"}}}],"researchProjects":[],"grants":[{"title":{"ja":"自己免疫疾患の根治を目標とする抗原特異性と遺伝子発現のシングルセル統合解析","en":"Single cell integrated analysis of antigen specificity and gene expression for the cure of autoimmune diseases"},"agency":{"ja":"科学研究費助成事業 若手研究","en":"KAKENHI Grant-in-Aid for Early-Career Scientists"},"grantIds":["20K17430"]},{"title":{"ja":"自己免疫疾患の病変部位における自己抗体の産生機構の解明","en":"Elucidation of the Mechanisms of Autoantibody Production at Lesion Sites in Autoimmune Diseases"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["22K08528"]},{"title":{"ja":"自己免疫疾患の抗原特異性の詳細解析による疾患制御法の確立","en":"Establishing Disease Control Methods Through Detailed Analysis of Antigen Specificity in Autoimmune Diseases"},"agency":{"ja":"JSR・JKiC次世代プロジェクト","en":"JSR・JKiC Next-generation Project"},"grantIds":null},{"title":{"ja":"自己免疫疾患の病変局所における自己免疫機構の解明と抗原特異的免疫抑制療法の開発","en":"Elucidation of Autoimmune Mechanisms at Lesion Sites in Autoimmune Diseases and Development of Antigen-Specific Immunosuppressive Therapies"},"agency":{"ja":"慶應義塾大学 学事振興資金","en":"Keio University Academic Promotion Fund"},"grantIds":null},{"title":{"ja":"自己免疫の全容解明と抗原特異的免疫抑制療法の実用化","en":"Comprehensive Understanding of Autoimmunity and Practical Application of Antigen-Specific Immunosuppressive Therapies"},"agency":{"ja":"慶應義塾大学 福澤基金","en":"Keio University Fukuzawa Memorial Fund"},"grantIds":null},{"title":{"ja":"自己免疫応答の場としてとらえる唾液腺病変の包括的解明","en":"Comprehensive Analysis of Salivary Gland Lesions as Sites of Autoimmune Responses"},"agency":{"ja":"慶應義塾大学 次世代研究プロジェクト推進プログラム","en":"Keio University Next-Generation Research Promotion Program"},"grantIds":null},{"title":{"ja":"シェーグレン症候群の病変組織における自己免疫機構の解明と抗原特異的免疫抑制療法の開発","en":"lucidation of Autoimmune Mechanisms in Lesional Tissues of Sjögren's Syndrome and Development of Antigen-Specific Immunosuppressive Therapies"},"agency":{"ja":"持田記念医学薬学振興財団 研究助成","en":"Mochida Memorial Foundation for Medical and Pharmaceutical Research - Research Grant -"},"grantIds":null},{"title":{"ja":"シェーグレン症候群の病変部位における自己免疫反応に関わる分子機構の解明","en":"Elucidation of Molecular Mechanisms Involved in Autoimmune Responses at Lesion Sites in Sjögren's Syndrome"},"agency":{"ja":"興和生命科学振興財団 研究助成","en":"Kowa Life Science Foundation - Research Grant -"},"grantIds":null},{"title":{"ja":"自己免疫疾患の病変局所における自己免疫機構の解明","en":"Elucidation of Autoimmune Mechanisms at Lesion Sites in Autoimmune Diseases"},"agency":{"ja":"武田科学振興財団 医学系研究助成","en":"Takeda Science Foundation - Medical Research Grant -"},"grantIds":null},{"title":{"ja":"自己免疫疾患の自己免疫応答に関わる分子標的の同定","en":"Identification of molecular targets involved in autoimmune responses in autoimmune diseases"},"agency":{"ja":"アステラス病態代謝研究会 研究助成","en":"The Astellas Foundation for Research on Metabolic Disorders - Research Grant -"},"grantIds":null},{"title":{"ja":"シェーグレン症候群の自己抗原特異的免疫抑制療法の開発","en":"Development of autoantigen-specific immunosuppressive therapy for Sjögren's Disease"},"agency":{"ja":"先進医薬研究振興財団 血液医学分野 一般研究助成","en":"The SENSHIN Medical Research Foundation - Research Grant -"},"grantIds":null},{"title":{"ja":"関節リウマチ由来滑膜線維芽細胞を用いた人工滑膜の創生","en":"Creation of Artificial Synovium Using Synovial Fibroblasts Derived from Rheumatoid Arthritis"},"agency":{"ja":"中冨健康科学振興財団","en":"The Nakatomi Foundation - Research Grant -"},"grantIds":null},{"title":{"ja":"自己免疫疾患に対する抗原特異的免疫抑制療法の実用化","en":"Development of Autoantigen-Specific Immunosuppressive Therapy for autoimmune disease"},"agency":{"ja":"高橋産業経済研究財団","en":"The Takahashi Industrial Economic Research Foundation - Research Grant -"},"grantIds":null},{"title":{"ja":"自己免疫と炎症の両面から迫る自己免疫疾患の分子病態解析","en":"Molecular Pathogenesis Analysis of Autoimmune Diseases from Both Autoimmunity and Inflammation Perspectives"},"agency":{"ja":"日本ワックスマン財団 学術研究助成金","en":"The Waksman Foundation of Japan INC - Research Grant -"},"grantIds":null},{"title":{"ja":"自己免疫の維持に関わる分子機構の解明","en":"Elucidation of the molecular mechanisms involved in maintaining autoimmunity"},"agency":{"ja":"冲中成人病研究所 研究費助成","en":"Okinaka Memorial Institute for Medical Research"},"grantIds":null}],"relatedPublications":[],"datasets":["JGAD000950"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000950"]}]}