{"id":"hum0517","version":1,"url":"https://humandbs.dbcls.jp/research/hum0517/v1","datePublished":"2025-06-17","versions":[{"version":1,"datePublished":"2025-06-17"}],"title":{"ja":"婦人科がん初代培養細胞を用いた新規治療法の評価および効果予測因子の探索","en":"Evaluation of novel therapies using primary cultured gynecological cancer cells and search for predictors of efficacy"},"summary":{"aims":{"ja":"婦人科悪性腫瘍症例由来の腫瘍組織あるいは細胞を用いて、抗腫瘍効果や生物学的な活性をin vivoで評価するための最適な方法を確立し、実際に当該方法を用いて評価することにより、婦人科がんの新規治療法の開発に貢献すること。","en":"To establish an optimal method to evaluate the anti-tumor efficacy and biological activity in vivo using tumor tissues and cells derived from patients with gynecological malignancies, and to evaluate them in practice. This research will contribute to the development of new treatments for gynecological cancer."},"methods":{"ja":"Whole Exome Sequencing解析","en":"Whole exome sequencing analysis"},"targets":{"ja":"子宮体がん30症例の腫瘍組織、および腫瘍組織を免疫不全マウスに移植したpatient-derived xenograft（PDX）において増殖した腫瘍組織","en":"Endometrial cancer 30 cases and tumor tissues propagated in patient-derived xenografts (PDXs)"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"子宮体癌：30症例\n（日本人）","en":"Endometrial cancer: 30 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome）","en":"NGS\n(Exome)"}},"releaseNote":{"ja":"子宮体がん30症例の腫瘍組織およびPDX腫瘍組織から抽出したDNAを用いたWhole Exome Sequencing解析データをbamファイルにて提供する。","en":"DNA extracted from tumor tissues from patients with endometrial cancer and tumor tissues from PDX using patient specimens were used for the whole exome sequencing analysis. Bam files are provided."},"dataProviders":[{"name":{"ja":"長谷川 幸清","en":"Kosei Hasegawa"},"organization":{"name":{"ja":"埼玉医科大学国際医療センター 婦人科腫瘍科","en":"Department of Gynecologic Oncology, Saitama Medical University International Medical Center"}}}],"researchProjects":[{"name":{"ja":"EC-PDXプロジェクト","en":"EC-PDX project"},"url":{"ja":null,"en":null}}],"grants":[],"relatedPublications":[{"title":"Establishing a comprehensive panel of patient-derived xenograft models for high-grade endometrial carcinoma: molecular subtypes, genetic alterations, and therapeutic target profiling","doi":"https://doi.org/10.1016/j.neo.2025.101158","datasets":["JGAD000951"]}],"datasets":["JGAD000951"],"controlledAccessUsers":[]}