{"id":"hum0513","version":1,"url":"https://humandbs.dbcls.jp/research/hum0513/v1","datePublished":"2026-09-08","versions":[{"version":1,"datePublished":"2026-09-08"}],"title":{"ja":"COVID-19ワクチン接種対象者における免疫応答の解析","en":"Immune profiling study of COVID-19 vaccine recipients"},"summary":{"aims":{"ja":"日本で承認済みのCOVID-19ワクチン接種対象者の抗体や免疫細胞を網羅的に解析し、ワクチンの効果や副反応および有害事象と相関する因子を同定すること。","en":"To comprehensively analyze antibodies and immune cells in individuals who received approved COVID-19 vaccines in Japan and to identify factors correlated with vaccine efficacy, adverse reactions, and adverse events."},"methods":{"ja":"scRNA-seq、scTCR-seq","en":"scRNA-seq, scTCR-seq"},"targets":{"ja":"COVID-19ワクチン接種者（健常人）14名","en":"14 Healthy donors who received COVID-19 vaccines"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"COVID-19ワクチン接種者（健常人）：14名\n（日本人）","en":"14 healthy donors who received COVID-19 vaccines\n(Japanese)"},"typeOfData":{"ja":"NGS\n（scRNA-seq、scTCR-seq）","en":"NGS\n(scRNA-seq, scTCR-seq)"}},"releaseNote":{"ja":"COVID-19ワクチン接種者（健常人）14名のワクチン3回目接種から1年後に採血した末梢血単核球（PBMC）を用いたscRNA-seqおよびscTCR-seq解析データをfastq、bam、h5、json、csvファイル形式で提供する。","en":"PBMCs isolated from peripheral blood of 14 healthy donors who received COVID-19 vaccines were used for scRNA-seq and scTCR-seq analyses. Fastq, bam, h5, json and csv files are provided."},"dataProviders":[{"name":{"ja":"高橋 宜聖","en":"Yoshimasa Takahashi"},"organization":{"name":{"ja":"国立感染症研究所 治療薬・ワクチン開発研究センター","en":"Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases"}}}],"researchProjects":[],"grants":[{"title":{"ja":"ウイルス免疫逃避に対抗する液性免疫記憶の進化機序の解明","en":"Evolution of humoral immune memory for resisting viral escape"},"agency":{"ja":"日本医療研究開発機構 革新的先端研究開発支援事業 ユニットタイプ（AMED-CREST）","en":"Core Research and Evolutional Science and Technology, Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED-CREST)"},"grantIds":["JP23gm1810004"]}],"relatedPublications":[{"title":"Antibody durability is influenced by interleukin-2 production by undifferentiated memory T helper cells and extensive B cell clonal expansion","doi":"https://doi.org/10.1016/j.celrep.2025.115934","datasets":["JGAD000937"]}],"datasets":["JGAD000937"],"controlledAccessUsers":[]}