{"id":"hum0505","version":1,"url":"https://humandbs.dbcls.jp/research/hum0505/v1","datePublished":"2025-05-30","versions":[{"version":1,"datePublished":"2025-05-30"}],"title":{"ja":"アレルギー疾患における遺伝要因の探索研究","en":"Exploratory study of genetic factors in allergic diseases"},"summary":{"aims":{"ja":"気管支喘息、花粉症、アトピー性皮膚炎、食物アレルギーなどのアレルギー疾患の発症には、遺伝的要因が重要な役割を果たしている。本研究では、アレルゲン感作、アレルギー疾患発症、重症度、治療抵抗性（難治性）といった、アレルギー疾患関連形質にかかわる遺伝子の同定を目的とする。","en":"Genetic factors play an important role for the development of allergic diseases such as bronchial asthma, hay fever, atopic dermatitis, and food allergy. This study aims to identify genes involved in the pathogenesis of allergic diseases."},"methods":{"ja":"血液または唾液よりDNAを抽出し、SNPアレイによる遺伝子型決定を行った。","en":"DNA was extracted from blood or saliva and genotyped using the Infinium Asian Screening Array (illumina)."},"targets":{"ja":"成育コホートのゲノム解析研究に参加し、かつ、9歳時のImmunoCAP ISACのデータが存在する564名。総IgE値については562名。","en":"Five hundred and sixty-four children who participated in T-Child study (a birth cohort study) with ImmunoCAP ISAC sIgE 112 data available at age 9 years."},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"ゲノムワイド\n関連","en":"Genome-wide association study"},"targets":{"ja":"成育コホート研究のゲノム解析研究参加者：564名\n（日本人）","en":"564 individuals who participated in the genomic analysis study of the adult cohort study\n(Japanese)"},"typeOfData":{"ja":"SNP-chip","en":"SNP-chip"}},"releaseNote":{"ja":"9歳時のImmunoCAP ISACによる特異的IgE検査を実施済みの564名の末梢血から抽出したDNAを用いて実施したGWAS統計量をテキスト形式にて提供する。","en":"DNA was extracted from peripheral blood cells/saliva of 564 children who participated in T-Child study (a birth cohort study) with ImmunoCAP ISAC sIgE 112 data available at age 9 years. Five hundred and sixty-two children for total serum IgE data. Genotyping was performed using the Asian Screening Array (illumina), followed by genome-wide association studies using the imputed genotypes (text file)."},"dataProviders":[{"name":{"ja":"野口 恵美子","en":"Emiko Noguchi"},"organization":{"name":{"ja":"筑波大学 医学医療系遺伝医学","en":"Faculty of Medicine, Department of Medical Genetics, University of Tsukuba"}}}],"researchProjects":[],"grants":[{"title":{"ja":"出生コホート研究によるアレルギー疾患の遺伝環境要因の解明","en":"Elucidation of Genetic and Environmental Factors in Allergic Disease using Birth Cohort Study"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["16H03269"]},{"title":{"ja":"疾患コホートと一般コホート研究の組み合わせによるアレルギー疾患発症ならびにアレルゲン免疫応答を予測するためのゲノム基盤構築","en":"Development of a prediction method for allergic diseases and allergen responsiveness using patients cohorts and general population cohorts"},"agency":{"ja":"日本医療研究開発機構（AMED）免疫アレルギー疾患実用化研究事業","en":"Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP20ek0410076"]},{"title":{"ja":"成育医療におけるゲノム情報を含む長期追跡データの構築と病因解明に関するコホート研究","en":"A birth cohort study on the establishment of long-term follow-up data with genetic information and the elucidation of disease etiology in perinatal and pediatric medicine"},"agency":{"ja":"国立成育医療研究センター 成育医療研究開発費","en":"National Center for Child Health and Development (NCCHD)"},"grantIds":["26-18"]}],"relatedPublications":[{"title":"A genome-wide association study for allergen component sensitizations identifies allergen component-specific and allergen protein group-specific associations","doi":"https://doi.org/10.1016/j.jacig.2023.100086","datasets":["NHA000201"]}],"datasets":["NHA000201"],"controlledAccessUsers":[]}