{"id":"hum0502","version":1,"url":"https://humandbs.dbcls.jp/research/hum0502/v1","datePublished":"2025-06-05","versions":[{"version":1,"datePublished":"2025-06-05"}],"title":{"ja":"体細胞ゲノム解析に基づく子宮頸がんの本態解明・治療標的の同定を目指す研究","en":"Elucidating the development of cervical cancer and identifying therapeutic targets based on cancer genome analysis"},"summary":{"aims":{"ja":"子宮頸がんの凍結組織検体を用いたトランスクリプトーム解析を実施することで、網羅的な遺伝子発現プロファイルを明らかにすること","en":"To clarify the comprehensive gene expression profiles, transcriptome analysis using frozen tumor tissues from patients with cervical cancer was conducted."},"methods":{"ja":"腫瘍組織から抽出したRNAを用いたRNAシークエンス解析を実施した","en":"RNA sequencing was conducted using RNA isolated from frozen cancer tissues obtained from the 29 patients with cervical cancer"},"targets":{"ja":"国立がんセンター中央病院において外科的治療を受けた子宮頸がん29症例","en":"Twenty-nine patients with cervical cancer underwent surgical treatment at the National Cancer Center Hospital between 2002 and 2020"},"url":{"ja":[{"url":"https://ncc.bvits.com/rinri/publish_document.aspx?ID=38052","text":"https://ncc.bvits.com/rinri/publish_document.aspx?ID=38052"}],"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"子宮頸癌：29症例\n（日本人）","en":"cervical cancer: 29 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（RNA-seq）","en":"NGS\n(RNA-seq)"}},"releaseNote":{"ja":"子宮頸がん29症例の腫瘍組織から抽出したRNAを用いたRNA-seq解析データをfastqファイルにて提供する。","en":"RNAs extracted from tumor tissues from 29 patients with cervical cancer were used for RNA-sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"白石 航也","en":"Kouya Shiraishi"},"organization":{"name":{"ja":"国立がん研究センター研究所 臨床ゲノム解析部門","en":"Department of Clinical Genomics, National Cancer Center Research Institute"}}}],"researchProjects":[{"name":{"ja":"体細胞ゲノム解析に基づく子宮頸がんの本態解明・治療標的の同定を目指す研究","en":"Comprehensive Somatic Genomic Analysis to Uncover the Molecular Pathogenesis and Therapeutic Targets of Cervical Cancer"},"url":{"ja":[{"url":"https://ncc.bvits.com/rinri/publish_document.aspx?ID=38052","text":"https://ncc.bvits.com/rinri/publish_document.aspx?ID=38052"}],"en":null}}],"grants":[{"title":{"ja":"子宮頸がんに対する治療標的となりうる新規ゲノムプロファイリングの同定","en":"Identification of Novel Genomic Profiles as Potential Therapeutic Targets for Cervical Cancer"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["22K09563"]}],"relatedPublications":[],"datasets":["JGAD000945"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"菅原 正貴","en":"Masaki Sugawara"},"affiliation":{"ja":"産婦人科学教室, 慶應義塾大学医学部","en":"Department of Obstetrics & Gynecology, Keio University School of Medicine"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"がんバイオマーカーの探索と新規がん診断法・治療法の開発に関する研究","en":"A Study on the Identification of Cancer Biomarkers and the Development of Novel Diagnostic and Therapeutic Approaches for Cancer"},"periodStart":"2026-09-18","periodEnd":"2030-03-31","datasets":["JGAD000945"]}]}