{"id":"hum0501","version":1,"url":"https://humandbs.dbcls.jp/research/hum0501/v1","datePublished":"2025-05-15","versions":[{"version":1,"datePublished":"2025-05-15"}],"title":{"ja":"ゲノムアジア100Kプロジェクト：アジア集団のDNA試料収集と全ゲノム解析","en":"GenomeAsia 100K Project: Human DNA samples collecting and whole genome sequencing of Asian populations"},"summary":{"aims":{"ja":"北ユーラシアの先住民および南アメリカの先住民の集団間における基礎的な分岐数、混血度合、および孤立度合いについては議論が続いており、これまでの知見の多くは全ゲノムシークエンスデータに基づいている。本研究は、現在の北ユーラシアおよびアメリカの集団形成における古代のダイナミクスとその影響をより深く理解することを目的とし、これらの地域からの139の民族集団に属する1,537人の大規模な全ゲノムシークエンスデータを使用し、集団構造を特定し、先史時代の移住や環境が集団の多様化に果たした役割を明らかにする。","en":"The number of basal divergences, admixture, and the degrees of isolation among Indigenous North Eurasian and Native South American populations remain debated, with most insights derived from genome-wide genotyping data. This study aims to improve our understanding of the ancient dynamics and shaping of the contemporary populations of North Eurasia and the Americas. Using large-scale whole-genome sequencing of 1,537 individuals across 139 ethnic groups from these regions, we identify population structures, clarify the prehistoric migrations and the role of past environments in the diversification of human populations."},"methods":{"ja":"全ゲノムシークエンシング","en":"Whole genome sequencing"},"targets":{"ja":"約100の民族集団に属する健常者1,323名","en":"1,323 healthy individuals"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"約100の民族集団に属する健常者：1,323名","en":"1,323 individuals of ~100 ethnic groups"},"typeOfData":{"ja":"NGS\n（WGS）","en":"NGS\n(WGS)"}},"releaseNote":{"ja":"約100の民族集団に属する健常者1,323名分の全ゲノムバリアントコールデータをvcfファイルにて提供する。534名についてはGenomeAsia 100K Projectの既存のデータを使用し、799名については新規に全ゲノムシーケンシングを行った。","en":"Variant call data for 1,323 human whole genomes from healthy populations across ~100 ethnic groups are provided (vcf, tabix)."},"dataProviders":[{"name":{"ja":"Hie Lim Kim","en":"Hie Lim Kim"},"organization":{"name":{"ja":"Asian School of the Environment、Nanyang Technological University","en":"Asian School of the Environment, Nanyang Technological University"}}}],"researchProjects":[],"grants":[{"title":{"ja":null,"en":null},"agency":{"ja":"GenomeAsia 100K consortium","en":"GenomeAsia 100K consortium"},"grantIds":null}],"relatedPublications":[{"title":"From North Asia to South America: Tracing the longest human migration through genomic sequencing","doi":"https://doi.org/10.1126/science.adk5081","datasets":["JGAD000923"]}],"datasets":["JGAD000923"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"松前 ひろみ","en":"Hiromi Matsumae"},"affiliation":{"ja":"医学部分子生命科学領域, 東海大学","en":"Department of Molecular Life Sciences, School of Medicine, Tokai University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"アジア諸集団の遺伝的多様性解析","en":"Genome Diversity Analysis on Asian populations"},"periodStart":"2025-07-10","periodEnd":"2028-03-31","datasets":["JGAD000923"]},{"principalInvestigator":{"ja":"木村 亮介","en":"Ryosuke Kimura"},"affiliation":{"ja":"大学院医学研究科人体解剖学講座, 琉球大学","en":"Department of Human Biology and Anatomy, Graduate School of Medicine, University of the Ryukyus"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"ヒト全ゲノム配列基盤情報の整備および集団遺伝学・分子進化学解析","en":"Construction of a human genome reference dataset and its application to population genetics and molecular evolutionary analyses"},"periodStart":"2025-09-17","periodEnd":"2028-03-31","datasets":["JGAD000923"]},{"principalInvestigator":{"en":"Martin Kuhlwilm"},"affiliation":{"en":"Department of Evolutionary Anthropology, University of Vienna"},"country":{"ja":"オーストリア","en":"Austria"},"researchTitle":{"en":"Non-invasive genomic insights into the origin and final days of the Children of Llullaillaco - Population genetics analysis of local ancestry"},"periodStart":"2026-06-30","periodEnd":"2027-04-29","datasets":["JGAD000923"]}]}