{"id":"hum0500","version":1,"url":"https://humandbs.dbcls.jp/research/hum0500/v1","datePublished":"2026-05-15","versions":[{"version":1,"datePublished":"2026-05-15"}],"title":{"ja":"糖尿病性腎臓病の病態進行に関わる因子の解明","en":"Elucidation of factors involved in the progression of diabetic kidney disease"},"summary":{"aims":{"ja":"古典的糖尿病性腎症の経過として、初期に糸球体濾過量が増加し、顕性アルブミン尿（高度蛋白尿）を呈した後に腎機能が低下することが知られている。しかしながら近年、高度蛋白尿を認めない微量アルブミン尿の段階から急速に腎機能低下が進行する症例の存在（Rapid Decliner）が明らかにされ、問題視されている。そして現在、古典的糖尿病性腎症を含む、 糖尿病に伴う慢性腎臓病のより包括的な疾患概念として、糖尿病性腎臓病という新規概念が提唱されている。糖尿病性腎臓病において、古典的糖尿病性腎症とRapid Declinerの経過を分ける因子やその分子機構を解明することで、症例・病態に応じた有効な診断法および治療法を開発する。","en":"In recent years, it has become apparent that there are cases where kidney function declines rapidly from the stage of microalbuminuria without high-grade proteinuria (rapid decliner), which is different from the classic course of diabetes, and this has become a problem.In addition, a new concept of diabetic kidney disease has been proposed as a more comprehensive disease concept for chronic kidney disease associated with diabetes.The factors and molecular mechanisms that determine the course of diabetic nephropathy, whether it is the classic diabetic nephropathy or the rapid decliner, are unknown.In order to develop effective diagnostic and therapeutic methods for individual cases and conditions of diabetic nephropathy patients, it is necessary to elucidate the molecular mechanisms."},"methods":{"ja":"single-cell RNA-seq","en":"single-cell RNA-seq"},"targets":{"ja":"10年以上の糖尿病罹患歴があり、以下のクライテリアに該当する者：①直近の外来受診時の腎機能マーカ（eGFR）が60 mL/min/1.73m²未満、②20歳から75歳、③男性、④RAS阻害薬内服有、⑤SGLT2阻害薬内服無、⑥腎生検を予定している","en":"Male patients aged 20 to 75 years with a history of diabetes for more than 10 years, an eGFR of less than 60 mL/min/1.73m² at their most recent outpatient visit, who were taking a RAS inhibitor but not a SGLT2 inhibitor and were scheduled to undergo a renal biopsy."},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"糖尿病性腎臓病：3症例\n（日本人）","en":"diabetic kidney disease: 3 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（scRNA-seq）","en":"NGS\n(scRNA-seq)"}},"releaseNote":{"ja":"糖尿病性腎臓病（Rapid Decliner群）3症例の腎生検から抽出したRNAを用いたsingle cell RNA-seq解析結果をfastqファイルにて提供する。","en":"RNAs extracted from kidney tissues of 3 cases of rapid decline in diabetic kidney disease were used for the single cell RNA-seq analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"涌井 広道","en":"Hiromichi Wakui"},"organization":{"name":{"ja":"横浜市立大学医学部 循環器・腎臓・高血圧内科学","en":"Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine"}}}],"researchProjects":[{"name":{"ja":"糖尿病性腎臓病の病態進行に関わる因子の解明","en":"Elucidating factors associated with the progression of diabetic kidney disease"},"url":{"ja":null,"en":null}}],"grants":[],"relatedPublications":[],"datasets":["JGAD000944"],"controlledAccessUsers":[]}