{"id":"hum0493","version":1,"url":"https://humandbs.dbcls.jp/research/hum0493/v1","datePublished":"2025-07-24","versions":[{"version":1,"datePublished":"2025-07-24"}],"title":{"ja":"皮膚免疫担当細胞の機能解析","en":"Functional analysis of skin immunocompetent cells"},"summary":{"aims":{"ja":"皮膚の免疫担当細胞と皮膚構造保持に働く間質細胞との相互作用を検討し、機能を分析する","en":"Examine the interaction between the cells responsible for skin immunity and the stromal cells that maintain the structure of the skin. Then analyse their function."},"methods":{"ja":"Xeniumによる空間トランスクリプトーム解析","en":"10x Xenium spatial transcriptome"},"targets":{"ja":"正常皮膚3検体","en":"Healthy skin from 3 individuals"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"健常皮膚：3例\n（日本人）","en":"Healthy skin: 3 individuals\n(Japanese)"},"typeOfData":{"ja":"Xenium In Situ Gene Expression","en":"Xenium In Situ Gene Expression"}},"releaseNote":{"ja":"3名の正常皮膚組織を用いたXenium解析結果一式（ome.tif、parquet、barcodes.tsv.gz、features.tsv.gz、matrix.mtx.gz、csv.gz、matrix.zarr）を提供する。","en":"Healthy skin from 3 individuals were used for Xenium In Situ Gene Expression Assay. Ome.tif, parquet, barcodes.tsv.gz, features.tsv.gz, matrix.mtx.gz, csv.gz and matrix.zarr files are provided."},"dataProviders":[{"name":{"ja":"吉岡 華子","en":"Hanako Koguchi-Yoshioka"},"organization":{"name":{"ja":"大阪大学 神経皮膚症候群の治療法の開発と病態解析学寄附講座","en":"Department of Neurocutaneous Medicine, the University of Osaka"}}}],"researchProjects":[],"grants":[{"title":{"ja":"Resident memory T細胞の可塑性低下に伴う免疫老化機構の解明","en":"Elucidation of immunosenescence mechanisms associated with reduced plasticity of resident memory T cells"},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的先端研究開発支援事業","en":"Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP23gm6710019"]},{"title":{"ja":"皮膚慢性炎症性疾患の根底にある病因性resident memory T細胞の構築維持機構の解明","en":"Investigating how pathogenic resident memory T cells are established and maintained in chronic inflammatory skin conditions"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["24K02472"]},{"title":{"ja":"皮膚微小環境の加齢変化に伴う悪性腫瘍発生の予防戦略","en":"Preventive strategies for malignant tumor development associated with age-related changes in the skin microenvironment"},"agency":{"ja":"JSID's Fellowship Shiseido Research Grant","en":"JSID's Fellowship Shiseido Research Grant"},"grantIds":null},{"title":{"ja":"皮膚の加齢による微小環境とT細胞との相互作用の動態変化の検討","en":"Investigation of dynamic changes in the interaction between the aging skin microenvironment and T cells"},"agency":{"ja":"公益財団法人 中冨健康科学振興財団","en":"Nakatomi Foundation"},"grantIds":null},{"title":{"ja":"老化による皮膚微小環境の変化と皮膚悪性腫瘍発症の相関の検討","en":"Investigation of the correlation between age-related changes in the skin microenvironment and the development of cutaneous malignancies"},"agency":{"ja":"The Lydia O'Reilly Memorial Foundation for the Promotion of Dermatology","en":"The Lydia O'Reilly Memorial Foundation for the Promotion of Dermatology"},"grantIds":null},{"title":{"ja":"皮膚微小環境を軸とした皮膚resident memory T細胞の構築・機能維持機構の解明","en":"Elucidation of the mechanisms underlying the establishment and functional maintenance of skin-resident memory T cells centered on the skin microenvironment"},"agency":{"ja":"公益財団法人 武田科学振興財団 生命科学研究助成","en":"Takeda Science Foundation"},"grantIds":null}],"relatedPublications":[{"title":"Immunoregulatory microenvironment in the elderly skin","doi":"https://doi.org/10.1016/j.xjidi.2025.100401","datasets":["JGAD000913"]}],"datasets":["JGAD000913"],"controlledAccessUsers":[]}