{"id":"hum0492","version":1,"url":"https://humandbs.dbcls.jp/research/hum0492/v1","datePublished":"2025-08-12","versions":[{"version":1,"datePublished":"2025-08-12"}],"title":{"ja":"産学連携による免疫炎症性難病の新規医薬品開発を目指した探索研究","en":"Exploratory research aimed at developing new drugs for difficult-to-treat immune-inflammatory diseases through industry-academia collaboration"},"summary":{"aims":{"ja":"関節リウマチ、炎症性腸疾患、自己免疫性肝障害などの免疫炎症性疾患は、病態の理解や薬剤の開発により以前よりも予後は向上した。しかしながら一部の患者では、依然として治療効果が不十分であったり、多面的な副作用が出現するステロイド薬を中止できない現状がある。本研究では、新規に治療を開始するこれらの免疫炎症性疾患の治療前・後の血液および組織を用いた、新たな治療薬開発の標的となる遺伝子やたんぱく質などのバイオマーカーの同定を目指す。","en":"Although advances in our understanding of the disease mechanisms and the development of new drugs has improved the prognosis for patients with immune-inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease and autoimmune liver disease, there are still some patients who do not respond well to treatment or who are unable to discontinue the use of steroid drugs. This study aims to identify biomarkers, such as genes and proteins, that can be also used as new therapeutic targets in the blood and tissues of patients with these immune-inflammatory diseases who are starting new treatment."},"methods":{"ja":"シングルセルRNAシークエンス/TCR・BCRレパトア解析、空間的トランスクリプトーム解析（Visium）","en":"Single cell RNA sequencing/TCR/BCR repertoire analyses, Spatial transcriptome analysis (Visium)"},"targets":{"ja":"シェーグレン症候群 28症例、シェーグレン症候群の診断基準を満たさなかったSicca 10症例由来の唾液腺組織","en":"labial salivary glands from 28 patients with Sjögren's syndrome and 10 patients with Sicca"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現\n病理画像","en":"Expression profiling and histological imaging"},"targets":{"ja":"シェーグレン症候群：28症例\nSicca：10症例\n（日本人）","en":"28 Sjögren's syndrome\n10 Sicca\n(Japanese)"},"typeOfData":{"ja":"NGS\n（scRNA-seq/TCR/BCRレパトア解析、Visium Spatial Gene Expression）\n病理画像","en":"NGS (scRNA-seq/TCR/BCR repetoire, Visium Spatial Gene Expression), histological image"}},"releaseNote":{"ja":"シェーグレン症候群19症例、ならびに、シェーグレン症候群の診断基準を満たさなかったSicca 8症例の唾液腺組織から抽出したRNAを用いたRNA-seq/TCR/BCRレパトア解析データ、および、シェーグレン症候群15症例、ならびに、Sicca5症例の唾液腺組織を用いたVisium解析データをfastq、bam、csv、jpg/tiff形式で提供する。","en":"- RNAs extracted from labial salivary glands from 19 patients with Sjögren's syndrome and 8 patients with Sicca were used for the single-cell RNA sequencing/TCR/BCR repertoire analyses. Bam and csv files are provided.\n- Labial salivary glands from 15 patients with Sjögren's syndrome and 5 patients with Sicca were used for Visium Spatial Gene Expression Assays. Fastq and jpg/tiff files are provided."},"dataProviders":[{"name":{"ja":"竹下 勝","en":"Masaru Takeshita"},"organization":{"name":{"ja":"慶應義塾大学医学部 リウマチ・膠原病内科","en":"Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine"}}}],"researchProjects":[],"grants":[{"title":{"ja":"自己免疫疾患の根治を目標とする抗原特異性と遺伝子発現のシングルセル統合解析","en":"Single cell integrated analysis of antigen specificity and gene expression for the cure of autoimmune diseases"},"agency":{"ja":"科学研究費助成事業 若手研究","en":"KAKENHI Grant-in-Aid for Early-Career Scientists"},"grantIds":["20K17430"]},{"title":{"ja":"自己免疫疾患の病変部位における自己抗体の産生機構の解明","en":"Elucidation of the Mechanisms of Autoantibody Production at Lesion Sites in Autoimmune Diseases"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["22K08528"]},{"title":{"ja":"レトロトランスポゾン領域を介したシェーグレン症候群の病態機序の解明","en":"Elucidation of Sjögren's syndrome pathogenesis through retrotransposon sequences"},"agency":{"ja":"科学研究費助成事業 特別研究員奨励費","en":"KAKENHI Grant-in-Aid for JSPS Fellows"},"grantIds":["21J00596"]},{"title":{"ja":"プレRAのマルチオミックス解析を用いた分子病態に関する研究","en":"Molecular signatures in pre-RA patients by multi-omics analysis"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["20H03720"]},{"title":{"ja":"自己免疫疾患の病変局所における自己免疫機構の解明と抗原特異的免疫抑制療法の開発","en":"Elucidation of Autoimmune Mechanisms at Lesion Sites in Autoimmune Diseases and Development of Antigen-Specific Immunosuppressive Therapies"},"agency":{"ja":"慶應義塾大学 学事振興資金","en":"Keio University Academic Promotion Fund"},"grantIds":null},{"title":{"ja":"自己免疫の全容解明と抗原特異的免疫抑制療法の実用化","en":"Comprehensive Understanding of Autoimmunity and Practical Application of Antigen-Specific Immunosuppressive Therapies"},"agency":{"ja":"慶應義塾大学 福澤基金","en":"Keio University Fukuzawa Memorial Fund"},"grantIds":null},{"title":{"ja":"自己免疫応答の場としてとらえる唾液腺病変の包括的解明","en":"Comprehensive Analysis of Salivary Gland Lesions as Sites of Autoimmune Responses"},"agency":{"ja":"慶應義塾大学 次世代研究プロジェクト推進プログラム","en":"Keio University Next-Generation Research Promotion Program"},"grantIds":null},{"title":{"ja":"シェーグレン症候群の病変組織における自己免疫機構の解明と抗原特異的免疫抑制療法の開発","en":"lucidation of Autoimmune Mechanisms in Lesional Tissues of Sjögren's Syndrome and Development of Antigen-Specific Immunosuppressive Therapies"},"agency":{"ja":"持田記念医学薬学振興財団 研究助成","en":"Mochida Memorial Foundation for Medical and Pharmaceutical Research - Research Grant -"},"grantIds":null},{"title":{"ja":"シェーグレン症候群の病変部位における自己免疫反応に関わる分子機構の解明","en":"Elucidation of Molecular Mechanisms Involved in Autoimmune Responses at Lesion Sites in Sjögren's Syndrome"},"agency":{"ja":"興和生命科学振興財団 研究助成","en":"Kowa Life Science Foundation - Research Grant -"},"grantIds":null},{"title":{"ja":"自己免疫疾患の病変局所における自己免疫機構の解明","en":"Elucidation of Autoimmune Mechanisms at Lesion Sites in Autoimmune Diseases"},"agency":{"ja":"武田科学振興財団 医学系研究助成","en":"Takeda Science Foundation - Medical Research Grant -"},"grantIds":null},{"title":{"ja":"各種自己免疫疾患における自己抗原特異的B細胞の免疫応答に関わる分子機構の解明と治療標的の同定","en":"Elucidation of Molecular Mechanisms Involved in Autoantigen-Specific B Cell Immune Responses in Various Autoimmune Diseases and Identification of Therapeutic Targets"},"agency":{"ja":"日本リウマチ財団 リウマチ性疾患調査・研究助成","en":"Japan Rheumatism Foundation - Research Grant for Rheumatic Disease Investigation -"},"grantIds":null}],"relatedPublications":[],"datasets":["JGAD000915"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000915"]}]}