{"id":"hum0484","version":1,"url":"https://humandbs.dbcls.jp/research/hum0484/v1","datePublished":"2025-06-24","versions":[{"version":1,"datePublished":"2025-06-24"}],"title":{"ja":"ヒト体細胞から樹立したInduced Pluripotent Stem Cell Line（iPS細胞株）のバンク事業","en":"Banking of induced pluripotent stem cell lines (iPS cell lines) established from human somatic cells"},"summary":{"aims":{"ja":"生命科学全体の基盤の整備・強化のため、理化学研究所バイオリソース研究センター（理研BRC）に寄託・譲渡されたヒトiPS細胞株について、細胞材料開発室が整備している細胞品質管理体制の下でヒトiPS細胞株を維持・管理し、高品質なヒトiPS細胞株を効率良く利用希望研究者へ提供することによって、様々な生命科学分野の発展に貢献することを目的とする。試料の付随情報を増やすことで試料の価値の向上を図るとともに、品質管理上必須となるため遺伝子解析等を可能な範囲内で実施して提供可能にする。","en":"The purpose is to contribute to the development of various fields of life science by providing human iPS cell lines to researchers who use them. Established human iPS cell lines will be deposited and transferred to the RIKEN BioResource Research Center (BRC), which will manage and supervise them under the cell quality control system. In this project, various characteristic analyses will be carried out to enhance the value of the samples by enriching the cell characteristics. Genetic information is crucial for sample quality control, so genetic analysis will be conducted to increase the value of the samples and provided as cell accompanying information."},"methods":{"ja":"Whole genome sequencing解析","en":"Whole genome sequencing"},"targets":{"ja":"筋萎縮性側索硬化症（amyotrophic lateral sclerosis：ALS）の血液もしくは皮膚組織由来iPS細胞株","en":"iPS cell lines derived from peripheral blood cells or skin tissues of patients with amyotrophic lateral sclerosis (ALS)."},"url":{"ja":[{"url":"https://cell.brc.riken.jp","text":"https://cell.brc.riken.jp"}],"en":[{"url":"https://cell.brc.riken.jp/en/","text":"https://cell.brc.riken.jp/en/"}]}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"ALS：33症例\n（日本人）","en":"33 ALSs\n(Japanese)"},"typeOfData":{"ja":"NGS\n（WGS）","en":"NGS\n(WGS)"}},"releaseNote":{"ja":"筋萎縮性側索硬化症（ALS）33症例の血液もしくは皮膚組織由来iPS細胞株33検体から抽出したDNAを用いたwhole genome sequencing解析データをfastq、bam、bai、vcf、tabixファイルにて提供する。","en":"DNAs extracted from iPS cell lines derived from peripheral blood cells or skin tissues obtained from 33 patients with amyotrophic lateral sclerosis were used for the whole genome sequencing analysis. Fastq, bam, bai, vcf and tabix files are provided."},"dataProviders":[{"name":{"ja":"中村 幸夫","en":"Yukio Nakamura"},"organization":{"name":{"ja":"理化学研究所 バイオリソース研究センター","en":"RIKEN BioResource Research Center"}}}],"researchProjects":[{"name":{"ja":"細胞材料開発室","en":"Cell Engineering Division"},"url":{"ja":[{"url":"https://cell.brc.riken.jp","text":"https://cell.brc.riken.jp"}],"en":[{"url":"https://cell.brc.riken.jp/en/","text":"https://cell.brc.riken.jp/en/"}]}}],"grants":[],"relatedPublications":[],"datasets":[],"controlledAccessUsers":[]}