{"id":"hum0483","version":1,"url":"https://humandbs.dbcls.jp/research/hum0483/v1","datePublished":"2025-06-10","versions":[{"version":1,"datePublished":"2025-06-10"}],"title":{"ja":"ヒト試料の収集・分譲と臨床情報を利用した研究に関するご協力のお願い","en":"Request for cooperation regarding collection and distribution of human specimens and research using clinical information"},"summary":{"aims":{"ja":"慶應義塾大学医学部産婦人科バイオバンク（Keio Women's Health Biobank）では、婦人科腫瘍のオルガノイドを、臨床情報やマルチオミックスデータ、薬剤感受性試験の情報など共に国内外の研究機関・製薬企業などに提供することで、医学研究に貢献する。","en":"The Keio Women's Health Biobank, established by the Department of Obstetrics and Gynecology at Keio University School of Medicine, contributes to medical research by providing gynecologic tumor-derived organoids, along with associated clinical information, multi-omics data, and drug sensitivity profiles, to domestic and international research institutions and pharmaceutical companies."},"methods":{"ja":"卵巣がん（明細胞がん、高異型度漿液性がん）から作製したオルガノイドを対象とするwhole exome sequencingおよびRNA sequencing","en":"Whole exome sequencing, RNA sequencing"},"targets":{"ja":"Exome：卵巣明細胞腺がん11症例 （腫瘍由来オルガノイド11検体、非腫瘍組織11検体）\nRNA-seq：卵巣明細胞腺がん10症例 （腫瘍由来オルガノイド10検体）、高異型度漿液性がん7症例（腫瘍由来オルガノイド7検体）、AGR2をノックアウトした明細胞がんオルガノイド4検体、GFP過剰発現明細胞がんオルガノイド（コントロール）2検体","en":"Ovarian cancer\nExome: Ovarian clear cell carcinoma: 11 cases (tumor-derived organoid: 11 samples, normal tissue: 11 samples)\nRNA-seq: Ovarian clear cell carcinoma: 10 cases (tumor-derived organoid: 10 samples, AGR2 knockout clear cell carcinoma organoid: 4 samples, GFP overexpressed clear cell organoid as control: 2 samples)\nHigh-grade serous carcinoma: 7 cases (tumor-derived organoid: 7 samples)"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定\n発現","en":"Sequencing; Expression profiling"},"targets":{"ja":"卵巣明細胞腺癌：11症例\n高異型度漿液性癌：7症例\n（日本人）","en":"Ovarian clear cell carcinoma: 11 cases\nHigh-grade serous carcinoma: 7 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome、RNA-seq）","en":"NGS\n(Exome, RNA-seq)"}},"releaseNote":{"ja":"卵巣明細胞腺がん11症例および高異型度漿液性がん7症例の腫瘍由来オルガノイド、さらに明細胞がんオルガノイドに対するAGR2ノックアウト細胞およびGFP過剰発現細胞（コントロール）から抽出したDNA/RNAを用いたwhole exome sequencingおよびRNA sequencing解析データをfastqファイルにて提供する。","en":"DNA/RNA extracted from tumor-derived organoids created from ovarian cancer (clear cell carcinoma and high-grade serous carcinoma) were used for the whole exome sequencing and RNA sequencing analyses. Fastq files are provided."},"dataProviders":[{"name":{"ja":"千代田 達幸","en":"Tatsuyuki Chiyoda"},"organization":{"name":{"ja":"慶應義塾大学医学部 産婦人科","en":"Department of Obstetrics and Gynecology, Keio University School of Medicine"}}}],"researchProjects":[{"name":{"ja":"難治性卵巣癌の治療開発/婦人科腫瘍研究室 臨床腫瘍・臨床遺伝部門","en":"Therapeutic Development for Ovarian Cancer / Clinical Oncology and Clinical Genetics Lab"},"url":{"ja":null,"en":null}}],"grants":[{"title":{"ja":"卵巣癌の小分子RNA-mRNAネットワークに基づく核酸医薬の実現","en":"Development of Nucleic Acid Therapeutics Targeting Small RNA-mRNA Networks in Ovarian Cance"},"agency":{"ja":"科学研究費助成事業 若手研究","en":"KAKENHI Grant-in-Aid for Early-Career Scientists"},"grantIds":["19K18651"]},{"title":{"ja":"卵巣癌オルガノイドバンクの階層的オミクスによる難治性卵巣癌根治療法の実現","en":"Development of Curative Treatment for Refractory Ovarian Cancer Using Omics Analysis of Ovarian Cancer Organoid Banks"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["21H03079"]},{"title":{"ja":"PARP阻害剤の抵抗性獲得を防ぐーBRCA1/2変異オルガノイドの活用ー","en":"Overcoming PARP Inhibitor Resistance Acquisition - Utilizing BRCA1/2 Mutant Organoids -"},"agency":{"ja":"科学研究費助成事業 若手研究","en":"KAKENHI Grant-in-Aid for Early-Career Scientists"},"grantIds":["21K16822"]}],"relatedPublications":[{"title":"High-throughput drug screening of clear cell ovarian cancer organoids reveal vulnerability to proteasome inhibitors and dinaciclib and identify AGR2 as a therapeutic target","doi":"https://doi.org/10.1158/2767-9764.CRC-25-0024","datasets":["JGAD000905"]}],"datasets":["JGAD000905"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"松村 謙臣","en":"Noriomi Matsumura"},"affiliation":{"ja":"産科婦人科学教室, 近畿大学医学部","en":"Obstetrics and Gynecology, Kindai University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"JGOG3017-TR1：エクソームシークエンスデータを有する卵巣明細胞癌のRNAseq解析","en":"Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1"},"periodStart":"2024-10-15","periodEnd":"2027-12-31","datasets":["JGAD000905"]},{"principalInvestigator":{"ja":"山口 建","en":"Ken Yamaguchi"},"affiliation":{"ja":"婦人科学産婦人科学教室, 京都大学","en":"Gynecology and Obstetrics, Kyoto University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"JGOG3017-TR1：エクソームシークエンスデータを有する卵巣明細胞癌のRNAseq解析","en":"Integrated multi-omics analysis for ovarian clear cell adenocarcinoma: JGOG3017-TR1"},"periodStart":"2024-10-22","periodEnd":"2027-12-31","datasets":["JGAD000905"]}]}