{"id":"hum0481","version":1,"url":"https://humandbs.dbcls.jp/research/hum0481/v1","datePublished":"2024-11-25","versions":[{"version":1,"datePublished":"2024-11-25"}],"title":{"ja":"日本人高齢者に多い疾患のゲノム解析および臨床ゲノム情報ストレージの整備","en":"Genome analysis of common diseases among older Japanese adults and development of clinical genome information storage"},"summary":{"aims":{"ja":"アルツハイマー病発症関連遺伝子の同定と疾患予測モデルへの応用","en":"Identification of genes associated with Alzheimer's disease and its application of the disease prediction model"},"methods":{"ja":"血液細胞の網羅的遺伝子発現解析（RNA-seq）","en":"RNA-seq of peripheral blood cells"},"targets":{"ja":"アルツハイマー病症例、軽度認知障害症例、健常者（認知機能正常）","en":"Alzheimer's disease, Mild cognitive impairment Alzheimer's disease, Mild cognitive impairment"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"アルツハイマー病：424症例\n軽度認知障害：543症例\n認知機能正常：260名\n（日本人）","en":"Alzheimer's disease: 424 cases\nMild cognitive impairment Alzheimer's disease: 543 cases\nMild cognitive impairment: 260 individuals\n(Japanese)"},"typeOfData":{"ja":"NGS\n（RNA-seq）","en":"NGS\n(RNA-seq)"}},"releaseNote":{"ja":"アルツハイマー病424症例、軽度認知障害543症例、 健常者（認知機能正常）260名の末梢血から抽出したRNAを用いたRNA-seq解析データより算出した発現量（TPM）データをtextファイルにて提供する。","en":"RNAs extracted from peripheral blood cells obtained from Alzheimer's disease, mild cognitive impairment Alzheimer's disease, and mild cognitive impairment individuals were used for RNA-sequencing analysis. TPM file is provided (txt)."},"dataProviders":[{"name":{"ja":"重水 大智","en":"Daichi Shigemizu"},"organization":{"name":{"ja":"国立研究開発法人 国立長寿医療研究センター メディカルゲノムセンター","en":"Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology"}}}],"researchProjects":[],"grants":[{"title":{"ja":"「認知症発症関連因子・機械モジュールの探索と人工知能を用いた発症予測モデルの開発」に関する研究","en":"Exploration of dementia-related factors and modules and development of a risk prediction model using AI"},"agency":{"ja":"国立長寿医療研究センター 長寿医療研究開発費","en":"Research Funding for Longevity Sciences, National Center for Geriatrics and Gerontology"},"grantIds":["21-24"]},{"title":{"ja":"大規模ゲノム解析における老年病発症関連遺伝子変異の同定と人工知能による発症リスク予測モデルの開発","en":"Identifying genetic mutations related to geriatric diseases through large-scale genome analysis and developing risk prediction models using AI"},"agency":{"ja":"国立長寿医療研究センター 長寿医療研究開発費","en":"Research Funding for Longevity Sciences, National Center for Geriatrics and Gerontology"},"grantIds":["24-11"]}],"relatedPublications":[{"title":"Alzheimer's disease may develop from changes in the immune system, cell cycle, and protein processing following alterations in ribosome function","doi":"https://doi.org/10.1038/s41598-025-93590-5","datasets":["JGAD000896"]}],"datasets":["JGAD000896"],"controlledAccessUsers":[]}