{"id":"hum0470","version":1,"url":"https://humandbs.dbcls.jp/research/hum0470/v1","datePublished":"2025-07-08","versions":[{"version":1,"datePublished":"2025-07-08"}],"title":{"ja":"免疫治療が施行された尿路上皮癌における予後調査とゲノムプロファイルの解明","en":"Prognostic Investigation and Genomic Profiling of Urothelial Carcinoma Treated with Immunotherapy"},"summary":{"aims":{"ja":"尿路上皮がん症例の免疫治療後の予後を調査するとともに、病理診断後の組織検体を用いたゲノム不安定性の有無を明らかにすることで、ゲノム不安定性の有無が尿路上皮がんへの免疫治療の効果を正確に反映し、治療の継続・変更を判断するための有用なバイオマーカー（病気の有無や進行度、治療効果の指標）となりうるか、また、新規薬剤の開発に繋がる医療情報となりうるかについて検討する。","en":"The aim of this study is to investigate the prognosis of patients with urothelial carcinoma who have undergone immunotherapy and to assess the presence/absence of genomic instability using tumor tissue obtained after pathological diagnosis. By clarifying whether genomic instability accurately reflects the efficacy of immunotherapy in urothelial carcinoma, we will evaluate its potential as useful biomarkers for determining whether to continue or modify treatment. Furthermore, we will explore its potential utility as clinical information that could contribute to the development of novel therapeutic agents."},"methods":{"ja":"Whole exome sequencing、RNA sequencing、Whole genome sequencing、single cell RNA sequencing、空間的トランスクリプトーム解析（Visium）","en":"Whole exome sequencing, RNA sequencing, Whole genome sequencing, single-cell RNA sequencing, spatial transcriptomics (Visium)"},"targets":{"ja":"尿路上皮がん（右腎臓の多発性遠隔転移を伴う局所進行腎盂がん）と診断され、免疫療法が施行された1症例。腫瘍組織検体は8臓器（原発巣、腫瘍周辺、後腹膜リンパ節、2つの異なる傍大動脈リンパ節、頸部リンパ節、右肺転移、左肺転移）、もしくは5臓器（原発巣腫瘍中心、後腹膜リンパ節、傍大動脈リンパ節、頸部リンパ節、左肺転移）より取得。","en":"One patient diagnosed with urothelial carcinoma who received immunotherapy. Tumor tissues were obtained from either 8 organs (primary lesion, peritumoral region, retroperitoneal lymph nodes, two distinct para-aortic lymph nodes, cervical lymph nodes, right lung metastasis, and left lung metastasis) or 5 organs (central region of the primary tumor, retroperitoneal lymph nodes, para-aortic lymph nodes, cervical lymph nodes, and left lung metastasis)."},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定\n発現","en":"Sequencing; Expression profiling"},"targets":{"ja":"尿路上皮癌：1症例\n（日本人）","en":"Urothelial carcinoma: 1 case\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Exome、RNA-seq、WGS、scRNA-seq、Visium Spatial Gene Expression）\n病理画像","en":"NGS (Exome, RNA-seq, WGS, scRNA-seq, Visium Spatial Gene Expression); Histological image"}},"releaseNote":{"ja":"尿路上皮がんと診断され免疫療法が施行された1症例の8臓器（原発巣、腫瘍周辺、後腹膜リンパ節、2つの異なる傍大動脈リンパ節、頸部リンパ節、右肺転移、左肺転移）より得られた腫瘍組織から抽出したDNA/RNAを用いたWES解析、RNA-seq解析、WGS解析、scRNA-seq解析、Visium解析データをfastq、bam、tif、xlsxファイルにて提供する。","en":"DNAs/RNAs extracted from tumor tissues dissected from 8 different organs of a patient diagnosed with urothelial carcinoma who received immunotherapy were used for the whole exome sequencing, RNA sequencing, whole genome sequencing, single-cell RNA sequencing, and Visium analyses. Fastq, bam, tif, and xlsx files are provided."},"dataProviders":[{"name":{"ja":"田中 伸之","en":"Nobuyuki Tanaka"},"organization":{"name":{"ja":"慶應義塾大学医学部 泌尿器科学教室","en":"Department of Urology, Keio University School of Medicine"}}}],"researchProjects":[{"name":{"ja":"慶應義塾大学医学部泌尿器科学教室/東京大学大学院理学系研究科生物科学専攻角田研究室/東京科学大学総合研究院M&Dデータ科学センター","en":"Department of Urology, Keio University School of Medicine / Tsunoda Laboratory, Department of Biological Sciences, Graduate School of Science, The University of Tokyo / M&D Data Science Center, Institute of Integrated Research, Institute of Science Tokyo"},"url":{"ja":null,"en":null}}],"grants":[{"title":{"ja":"腫瘍免疫に注目した遺伝子発現と病理組織による粘液型脂肪肉腫の予後予測モデルの構築","en":"Prognostic modeling of myxoid liposarcoma by gene expression and histopathology with focus on tumor immunity"},"agency":{"ja":"科学研究費助成事業 若手研究","en":"KAKENHI Grant-in-Aid for Early-Career Scientists"},"grantIds":["20K16408"]},{"title":{"ja":"がん免疫療法治療前後の多領域シーケンス解析による治療効果関連因子の特定","en":"Identification of Treatment-Related Factors Using Multi-Region Analysis Before and After Cancer Immunotherapy"},"agency":{"ja":"科学研究費助成事業 若手研究","en":"KAKENHI Grant-in-Aid for Early-Career Scientists"},"grantIds":["22K15576"]},{"title":{"ja":"膀胱がんにおけるlong non-coding RNAが担う役割の解明","en":"Elucidation of the role of long non-coding RNA in bladder cancer"},"agency":{"ja":"科学研究費助成事業 基盤研究（C）","en":"KAKENHI Grant-in-Aid for Scientific Research (C)"},"grantIds":["23K08724"]},{"title":{"ja":"がん多様性をin situで見える化する解析プラットフォーム構築と臨床応用","en":"Establishment of a research platform for visualization of tumor heterogeneity and clinical application"},"agency":{"ja":"科学研究費助成事業 挑戦的研究（萌芽）","en":"KAKENHI Grant-in-Aid for Challenging Research (Exploratory)"},"grantIds":["21K19414"]},{"title":{"ja":"In situな尿路上皮がん免疫ゲノミクス多様性解析とリキッドバイオプシーの確立","en":"In situ analysis of diverse urothelial carcinoma immunogenomics and liquid biopsy study"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["22H03217","23K24476"]},{"title":{"ja":"がん免疫治療下における間質軌跡地図の空間解析と新しい間質リプログラミング法の確立","en":"Spatial Analysis of Stromal Trajectory Map and Establishment of New Stromal Reprogramming Method under Cancer Immunotherapy"},"agency":{"ja":"科学研究費助成事業 挑戦的研究（開拓）","en":"KAKENHI Grant-in-Aid for Challenging Research (Pioneering)"},"grantIds":["24K21301"]},{"title":{"ja":"泌尿器がんのクローン進化と腫瘍間質の空間解析による免疫治療耐性メカニズムの解明","en":"Clonal Evolution of Urologic Cancer and Spatial Analysis of Tumor Stroma to Elucidate Immunotherapy Resistance Mechanisms"},"agency":{"ja":"科学研究費助成事業 基盤研究（A）","en":"KAKENHI Grant-in-Aid for Scientific Research (A)"},"grantIds":["24H00649"]},{"title":{"ja":"画像変換と深層学習によるマルチオミクス統合解析と病態や薬剤応答機序の解明の方法論","en":"Integrated Multi-Omics Analysis Methodology with Image Transformation and Deep Learning for Pathophysiology and Drug Response Mechanisms"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["20H03240"]},{"title":{"ja":"オミクスデータを量子計算に導き量子古典ハイブリッド機械学習で予測モデルを作る方法","en":"Embed omics data to quantum computation and construct predictive models with quantum-classical hybrid machine learning"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["25K02261"]},{"title":{"ja":"細胞内サイバネティック・アバターの遠隔制御によって見守られる社会の実現","en":"Realization of a society watched over by remote control of intracellular cybernetic avatars"},"agency":{"ja":"JST ムーンショット型研究開発事業","en":"Moonshot R&D Program, Japan Science and Technology Agency (JST)"},"grantIds":["JPMJMS2217"]},{"title":{"ja":"生体環境からのAI駆動型1分子ナノポア計測法の開発","en":"Development of AI-driven single molecule nanopore measurement methods from biological environments"},"agency":{"ja":"JST 戦略的創造研究推進事業 CREST","en":"Core Research and Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST)"},"grantIds":["JPMJCR2231"]}],"relatedPublications":[],"datasets":["JGAD000858"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000858"]}]}