{"id":"hum0466","version":1,"url":"https://humandbs.dbcls.jp/research/hum0466/v1","datePublished":"2024-11-20","versions":[{"version":1,"datePublished":"2024-11-20"}],"title":{"ja":"健康長寿社会の実現を目指した大規模認知症コホート研究","en":"Japan Prospective Studies for Aging and Dementia (JPSC-AD) study"},"summary":{"aims":{"ja":"認知症及びうつ病の危険因子及び保護因子の同定、危険因子及び防御因子の全体像の解明、ならびに、予防対策の確立","en":"- Identification of risk and protective factors for dementia and depression\n- Elucidation of the overall picture of risk and protective factors for dementia and depression\n- Establishment of preventive strategy for dementia and depression"},"methods":{"ja":"DNAアレイによる遺伝型決定後Imputationを実施し、関連解析を行った。","en":"Genotyping, imputation, and genome-wide association study were performed."},"targets":{"ja":"Japan Prospective Studies Collaboration for Aging and Dementia （JPSC-AD）研究に参加する8施設で収集された地域住民9,479名","en":"Of the 9,479 community residents collected at the 8 facilities participating in the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study."},"url":{"ja":[{"url":"https://www.eph.med.kyushu-u.ac.jp/jpsc/","text":"https://www.eph.med.kyushu-u.ac.jp/jpsc/"}],"en":[{"url":"https://www.eph.med.kyushu-u.ac.jp/jpsc/en/","text":"https://www.eph.med.kyushu-u.ac.jp/jpsc/en/"}]}},"listingSummary":{"methods":{"ja":"ゲノムワイド\n関連","en":"Genome-wide association"},"targets":{"ja":"JPSC-AD研究参加者：9,479名\n（日本人）","en":"9,479 participants in the JPSC-AD study\n(Japanese)"},"typeOfData":{"ja":"SNP-chip","en":"SNP-chip"}},"releaseNote":{"ja":"JPSC-AD研究に参加する8施設で収集された地域住民11,957名のうち、DNAアレイにより遺伝型決定された9,479名について、参照配列（バイオバンクジャパン1037名ならびに1000ゲノムプロジェクト2504名のWGSデータ）を用いたImputation後、関連解析を実施した際の統計量をテキスト形式にて提供する。","en":"DNAs extracted from peripheral blood cells of 9,479 participants in the JPSC-AD study, were genotyped, imputed, and genome-wide association studies were performed (text file)."},"dataProviders":[{"name":{"ja":"二宮 利治","en":"Toshiharu Ninomiya"},"organization":{"name":{"ja":"九州大学 大学院医学研究院 衛生・公衆衛生学分野","en":"Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University"}}}],"researchProjects":[{"name":{"ja":"JPSC-AD研究","en":"JPSC-AD study"},"url":{"ja":[{"url":"https://www.eph.med.kyushu-u.ac.jp/jpsc/","text":"https://www.eph.med.kyushu-u.ac.jp/jpsc/"}],"en":[{"url":"https://www.eph.med.kyushu-u.ac.jp/jpsc/en/","text":"https://www.eph.med.kyushu-u.ac.jp/jpsc/en/"}]}}],"grants":[{"title":{"ja":"大規模前向きコホートデータを基盤とした認知症のゲノム・脳画像研究","en":"Genome and Neuroimaging Research on Dementia Based on Large-Scale Prospective Cohort Data"},"agency":{"ja":"日本医療研究開発機構（AMED） 認知症研究開発事業","en":"Research and Development Grants for Dementia, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP24dk0207053"]},{"title":{"ja":null,"en":null},"agency":{"ja":"サントリーホールディングス","en":"Suntory Holdings Limited"},"grantIds":null}],"relatedPublications":[{"title":"Common protein-altering variant in GFAP is associated with white matter lesions in the older Japanese population. npj Genomic Med","doi":"https://doi.org/10.1038/s41525-024-00431-x","datasets":["NHA000197"]}],"datasets":["NHA000197"],"controlledAccessUsers":[]}