{"id":"hum0447","version":1,"url":"https://humandbs.dbcls.jp/research/hum0447/v1","datePublished":"2026-06-09","versions":[{"version":1,"datePublished":"2026-06-09"}],"title":{"ja":"ゲノム異常解析に基づく、肝がん、膵がん、肺がん、胃がん、大腸がん、胆道がん、乳がん、食道がん、卵巣がん、子宮がん、膀胱がん、腎臓がん、頭頚部がん、骨軟部肉腫、悪性黒色腫の発生・進展の分子機構の解明","en":"Comprehensive genomic analysis to elucidate the molecular mechanism of initiation and progression of liver cancer, pancreatic cancer, lung cancer, stomach cancer, colorectal cancer, biliary tract cancer, breast cancer, esophageal cancer, uterine cancer, ovarian cancer, bladder cancer, kidney cancer, head and neck cancer, bone and soft tissue sarcoma, and malignant melanoma."},"summary":{"aims":{"ja":"難治がん（膵がん、肺がん、大腸がん、卵巣がん、子宮がん、食道がん、乳がん、膀胱がん、腎臓がん、頭頚部がん、骨軟部肉腫、悪性黒色腫）や欧米と比較して本邦に頻度が多いがん（胃がん、肝がん、胆道がん）を対象とし、網羅的かつ探索的なゲノム解析を実施することにより、ゲノム異常とこれらのがんの病態との相関についての全体像を明らかにする。すなわち、本研究のゴールは以下の3点である。 1．多数のがん臨床検体を用いて、そのゲノム異常の詳細を明らかにする 、2．その解析結果を元に、様々な治療に対する反応性や生命予後にかかわる腫瘍の悪性形質（転移、浸潤など）との相関に重点をおいて解析を進め、治療法選択の指標になるなど臨床的に有用な情報を抽出する、3．新しい有効な治療法や有用な診断方法を開発するための基盤構築を行う。","en":"Intractable cancers (pancreatic, lung, colorectal, ovarian, uterine, esophageal, breast, bladder, kidney, and head and neck cancers; bone and soft tissue sarcoma; and malignant melanoma), as well as cancers that are more common in Japan (gastric, liver, and biliary tract cancers), were targeted. To clarify the onco-genomic landscape in relation to pathological conditions, we are conducting comprehensive, exploratory genomic analyses with the following aims: 1. To clarify genomic abnormalities. 2. To identify correlations between genomic abnormalities and malignant phenotypes of tumors (e.g., metastasis and invasion) that affect responses to various therapies and prognosis. 3. To establish new effective treatments and diagnostic methods."},"methods":{"ja":"Whole Genome Sequencing 解析","en":"Whole Genome sequencing"},"targets":{"ja":"日本人大腸がん138症例の大腸腫瘍組織（腫瘍検体）と同一症例の血液細胞","en":"Colorectal tumor tissues and peripheral blood cells from 138 Japanese colorectal cancer patients"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"大腸癌：138症例\n（日本人）","en":"colorectal cancer: 138 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（WGS）","en":"NGS\n(WGS)"}},"releaseNote":{"ja":"日本人大腸がん138症例の腫瘍組織と非腫瘍組織（末梢血）から抽出したDNAを用いたWGS解析データをbamファイルにて提供する。","en":"DNAs extracted from tumor and non-tumor tissues from Japanese colorectal cancer patients were used for whole genome sequencing analysis. Bam files are provided."},"dataProviders":[{"name":{"ja":"柴田 龍弘","en":"Tatsuhiro Shibata"},"organization":{"name":{"ja":"国立がん研究センター研究所 がんゲノミクス研究分野","en":"Division of Cancer Genomics, National Cancer Center Research Institute"}}}],"researchProjects":[],"grants":[{"title":{"ja":"国際共同研究に資する大規模日本人がんゲノム・オミックス・臨床データ統合解析とゲノム予防・医療推進","en":"Establishment of a Large-Scale Integrated Japanese Cancer Genome, Multi-Omics, and Clinical Data Resource for International Collaborative Research, Genome-Based Prevention, and Precision Medicine."},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的がん医療実用化研究事業","en":"Practical Research for Innovative Cancer Control, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP25ck0106800"]}],"relatedPublications":[{"title":"Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer","doi":"https://doi.org/10.52843/cassyni.86lmq6","datasets":["JGAD000829"]}],"datasets":["JGAD000829"],"controlledAccessUsers":[]}