{"id":"hum0445","version":1,"url":"https://humandbs.dbcls.jp/research/hum0445/v1","datePublished":"2025-05-19","versions":[{"version":1,"datePublished":"2025-05-19"},{"version":2,"datePublished":"2025-11-17"}],"title":{"ja":"ゲノム解析に基づく肺がんの発生・進展の分子機構の解明","en":"Cancer genomics for elucidation of molecular mechanisms of carcinogenecis and progression in lung cancer"},"summary":{"aims":{"ja":"ヒト肺がん細胞における変異・欠失・増幅・過メチル化など、体細胞レベルで生じたゲノム異常と遺伝子発現変動を解析し、それらを臨床病理学的情報と対比し検討することで、肺がんの発生・進展の分子機構および特性を遺伝子レベルで明らかにすること。","en":"The objective of this project is to analyze genomic aberrations and gene expression changes such as mutations, deletions, amplifications, and hypermethylation in human lung cancer cells at the somatic cell level, and to contrast these with clinicopathological information to elucidate the molecular mechanisms and characteristics of lung cancer development and progression at the genetic level."},"methods":{"ja":"RNAシークエンス解析、全エクソームシークエンス解析","en":"RNA-seq, Whole exome sequencing"},"targets":{"ja":"肺腺がん362症例、非小細胞肺がん8症例","en":"Lung adenocarcinoma, Non-small cell lung cancer"},"url":{"ja":[{"url":"https://www.ncc.go.jp/jp/ri/division/genome_biology/index.html","text":"https://www.ncc.go.jp/jp/ri/division/genome_biology/index.html"}],"en":[{"url":"https://www.ncc.go.jp/en/ri/division/genome_biology/project/index.html","text":"https://www.ncc.go.jp/en/ri/division/genome_biology/project/index.html"}]}},"listingSummary":{},"releaseNote":{"ja":"肺腺がん362症例の腫瘍組織および非腫瘍組織から抽出したRNAを用いたRNA-seq解析データをfastqファイルにて提供する","en":"RNAs extracted from tumor tissues and non-tumor tissues from 362 lung adenocarcinoma cases were used for RNA-sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"河野 隆志","en":"Takashi Kohno"},"organization":{"name":{"ja":"国立がん研究センター研究所 ゲノム生物学研究分野","en":"Division of Genome Biology, National Cancer Center Research Institute"}}}],"researchProjects":[],"grants":[{"title":{"ja":"多層的疾患オミックス解析における、ゲノム情報に基づく創薬標的の網羅的探索を目指した研究","en":"Research aimed at a comprehensive exploration of drug targets based on genomic data in multi-layered disease omics analysis"},"agency":{"ja":"国立研究開発法人 医薬基盤・健康・栄養研究所 保健医療分野における基礎研究推進事業","en":"The Advanced Research for Medical Products Mining Program of the National Institute of Biomedical Innovation (NIBIO)"},"grantIds":["157974"]},{"title":{"ja":"RET融合遺伝子陽性の進行非小細胞肺癌に対する新規治療法の確立に関する研究","en":"Research on the establishment of a new treatment for advanced non-small cell lung cancer with RET fusion"},"agency":{"ja":"厚生労働科学研究費補助金 厚生科学基盤研究分野","en":"The Health, and Labor Sciences Research Expenses for Commission"},"grantIds":["201409013B"]},{"title":{"ja":"肺発がんドライバー変異であるがん遺伝子融合の発生機構の解明","en":"Study on molecular procedures developing oncogene fusion-positive lung cancer"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"KAKENHI Grant-in-Aid for Scientific Research (B)"},"grantIds":["26293200"]}],"relatedPublications":[{"title":"KIF5B-RET fusions in lung adenocarcinoma","doi":"https://doi.org/10.1038/nm.2644","datasets":["JGAD000897"]},{"title":"Development of lung adenocarcinomas with exclusive dependence on oncogene fusions","doi":"https://doi.org/10.1158/0008-5472.CAN-14-3282","datasets":["JGAD000897"]},{"title":"Druggable Oncogene Fusions in Invasive Mucinous Lung Adenocarcinoma","doi":"https://doi.org/10.1158/1078-0432.CCR-14-0107","datasets":["JGAD000897"]},{"title":"Passive Smoking-Induced Mutagenesis as a Promoter of Lung Carcinogenesis","doi":"https://doi.org/10.1016/j.jtho.2024.02.006","datasets":["JGAD000897"]},{"title":"Genomic Profiles of Pathogenic and Moderate-Penetrance Germline Variants Associated With Risk of Early-Onset Lung Adenocarcinoma","doi":"https://doi.org/10.1016/j.jtho.2025.06.005","datasets":["JGAD000897"]},{"title":"Mutation of CMTR2 in Lung Adenocarcinoma Alters RNA Alternative Splicing and Reveals Therapeutic Vulnerabilities","doi":"https://doi.org/10.1038/s41467-025-64821-0","datasets":["JGAD000897"]}],"datasets":["JGAD000897"],"controlledAccessUsers":[]}