{"id":"hum0442","version":1,"url":"https://humandbs.dbcls.jp/research/hum0442/v1","datePublished":"2024-12-06","versions":[{"version":1,"datePublished":"2024-12-06"}],"title":{"ja":"進行・再発非小細胞肺がんにおける免疫チェックポイント阻害剤の患者層別化マーカーに関する探索的研究","en":"Exploratory study for stratification marker of immune checkpoint inhibitor in patients with advanced or recurrent non-small cell lung cancer"},"summary":{"aims":{"ja":"抗PD-1/PD-L1抗体治療を行う進行・再発非小細胞肺がん患者における、血中アミノ酸プロファイルによる予後判別モデル（多変量判別式）の性能検証","en":"To evaluate the performance of a prognosis prediction model based on the plasma-free amino acid concentration profile for advanced and/or recurrent non-small cell lung cancer patients who will receive anti-PD-1/PD-L1 antibody therapy"},"methods":{"ja":"RNAシークエンス解析","en":"RNA-seq analysis"},"targets":{"ja":"抗PD-1/PD-L1抗体治療開始前の進行・再発非小細胞肺がん 20症例","en":"advanced or recurrent non-small cell lung cancer patients before administering anti-PD-1/PD-L1 antibody treatment"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"非小細胞肺癌：20症例\n（日本人）","en":"non-small cell lung cancer: 20 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（RNA-seq）","en":"NGS\n(RNA-seq)"}},"releaseNote":{"ja":"進行・再発非小細胞肺がん20症例の腫瘍組織（FFPE検体）から抽出したRNAを用いたRNA-seq解析データをfastqファイルにて提供する。また、リードカウントデータ、TPMデータをcsvファイルにて提供する。","en":"RNAs extracted from tumor tissues from 20 advanced or recurrent non-small cell lung cancer patients before administering anti-PD-1/PD-L1 antibody treatment were used for RNA-sequencing analysis. Fastq data, the read count and TPM data are provided (fastq and csv files)."},"dataProviders":[{"name":{"ja":"笹田 哲朗","en":"Tetsuro Sasada"},"organization":{"name":{"ja":"神奈川県立がんセンター 臨床研究所 がんワクチン・免疫センター","en":"Division of Cancer Immunotherapy, Kanagawa Cancer Center Reserach Institute"}}}],"researchProjects":[{"name":{"ja":"アミノ酸プロファイルによるがん免疫微小環境の代謝リプログラミング評価とがん免疫治療患者層別化技術の開発","en":"Exploratory study for stratification marker of immune checkpoint inhibitor in patients with advanced or recurrent non-small cell lung cancer"},"url":{"ja":null,"en":null}}],"grants":[{"title":{"ja":"患者層別化マーカー探索技術の開発/医療ニーズの高い特定疾患・薬剤に対する患者層別化基盤技術の開発","en":"Evaluation of metabolic reprogramming in tumor immune microenvironment through amino-acid profiling and its application for stratifying patients under cancer immunotherapy"},"agency":{"ja":"日本医療研究開発機構（AMED） 次世代治療・診断実現のための創薬基盤技術開発事業","en":"Project Focused on Developing Key Technology for Discovering and Manufacturing Drugs for Next-Generation Treatment and Diagnosis, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP19ae0101076"]}],"relatedPublications":[{"title":"Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinoma","doi":"https://doi.org/10.3389/fimmu.2024.1361992","datasets":["JGAD000805","E-GEAD-883"]}],"datasets":["JGAD000805","E-GEAD-883"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000805"]}]}