{"id":"hum0440","version":1,"url":"https://humandbs.dbcls.jp/research/hum0440/v1","datePublished":"2024-05-17","versions":[{"version":1,"datePublished":"2024-05-17"}],"title":{"ja":"神経・筋組織を用いた難治性神経筋疾患の臨床経過に関連する蛋白の解明","en":"Elucidation of proteins associated with the clinical course of refractory neuromuscular diseases using nerve and muscle tissue"},"summary":{"aims":{"ja":"孤発性筋萎縮性側索硬化症、脊髄小脳変性症などの神経変性疾患や筋ジストロフィー、多発性硬化症・視神経脊髄炎、筋炎及び重症筋無力症等の筋疾患、自己免疫性脳炎、慢性炎症性脱髄性多発根神経炎などの末梢神経障害の主たる原因は解明されていない。パーキンソン病や重症筋無力症では例外的に治療薬が多数開発されているものの、多くの場合は有効な治療が少なく、効果も限定されている。一方、同じ神経・筋疾患でも患者個人によって臨床経過や初発症状に差があることが知られている。この臨床経過に関連する蛋白を明らかとし、病態に適した治療方針を考案していく。","en":"The primary causes of neurodegenerative diseases, as well as peripheral nerve disorders like autoimmune encephalitis and chronic inflammatory demyelinating polyneuropathy, remain unclear. Although numerous therapeutic drugs have been developed for the conditions at hand, it is known that even within the same neurological and muscular diseases, there are differences in clinical progression and initial symptoms among individual patients. We aim to identify proteins related to this clinical progression and develop treatment strategies tailored to the pathology."},"methods":{"ja":"10x Visium FFPE with CytAssist","en":"10x Visium FFPE with CytAssist"},"targets":{"ja":"胸腺腫、胸腺過形成","en":"Thymoma, Thymic hyperplasia"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現\n病理画像","en":"Expression profiling; Histological imaging"},"targets":{"ja":"胸腺腫：7症例\n胸腺過形成：2症例\n（日本人）","en":"Thymoma: 7 cases\nThymic hyperplasia: 2 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Visium Spatial Gene Expression）\n病理画像","en":"NGS (Visium Spatial Gene Expression); Histological image"}},"releaseNote":{"ja":"胸腺腫7症例の腫瘍組織、ならびに、胸腺過形成2症例の胸腺過形成組織を用いたVisium空間トランスクリプトーム解析データをfastq、tif、png、csv、jsonファイルにて提供する。","en":"Tumor tissues from thymoma or thymic hyperplasia samples from thymic hyperplasia were used for Visium Spatial Gene Expression Assays. Fastq, tif, png, csv and json files are provided."},"dataProviders":[{"name":{"ja":"奥野 龍禎","en":"Tatsusada Okuno"},"organization":{"name":{"ja":"大阪大学大学院医学系研究科 神経内科学","en":"Department of Neurology, Osaka University Graduate School of Medicine"}}}],"researchProjects":[{"name":{"ja":"神経・筋組織を用いた難治性神経筋疾患の臨床経過に関連する蛋白の解明","en":"Elucidation of proteins associated with the clinical course of refractory neuromuscular diseases using nerve and muscle tissue"},"url":{"ja":[{"url":"https://www.med.osaka-u.ac.jp/pub/neurol/myweb6/consultation04_31.html","text":"https://www.med.osaka-u.ac.jp/pub/neurol/myweb6/consultation04_31.html"}],"en":null}}],"grants":[{"title":{"ja":"自己免疫性神経筋疾患の発症機構解明と治療カタログ化の試み","en":"Trial to elucidate of the pathogenesis of autoimmune neuromuscular diseases and catalogue their treatment"},"agency":{"ja":"科学研究費助成事業 基盤研究（B）","en":"Grants-in-Aid for Scientific Research Grant (B)"},"grantIds":["23H02826"]}],"relatedPublications":[{"title":"Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis thymoma","doi":"https://doi.org/10.1101/2024.02.05.579042","datasets":["JGAD000802","E-GEAD-747"]}],"datasets":["JGAD000802","E-GEAD-747"],"controlledAccessUsers":[]}