{"id":"hum0437","version":1,"url":"https://humandbs.dbcls.jp/research/hum0437/v1","datePublished":"2024-03-05","versions":[{"version":1,"datePublished":"2024-03-05"}],"title":{"ja":"悪性脳腫瘍の新たなバイオマーカー及び分子標的の探索とそれらの臨床応用に向けた多施設共同研究による遺伝子解析","en":"Genetic analysis of novel biomarkers and molecular targets for malignant brain tumors and their clinical application through multicenter collaborative research"},"summary":{"aims":{"ja":"悪性脳腫瘍は治療抵抗性の予後不良な悪性疾患である。近年、分子遺伝学解析が急速に進んだことで、予後や治療反応性の予測因子となりうる遺伝子変異がいくつか発見されている。本研究では、悪性脳腫瘍における遺伝子変異を網羅的に探索し、それらを臨床病理学的情報と併せて検討することで、腫瘍の発生または悪性化に関与する遺伝子、もしくは、診断・再発の早期発見のためのバイオマーカーとして有用な遺伝子、さらには標的治療の対象となりうる遺伝子を特定し、それらを臨床試験の付随研究や割り付け因子に応用することを目的とする。","en":"Malignant brain tumors are refractory to treatment and have a poor prognosis. In recent years, molecular genetic analyses of malignant brain tumors have rapidly progressed, and several genetic abnormalities have been found to be predictive of prognosis and response to treatments. In this study, we will comprehensively examine genetic abnormalities in malignant brain tumors and compare them with clinicopathological information to identify genes that are involved in tumor development or malignant transformation, or that are useful as biomarkers for diagnosis and early detection of recurrence, and that may be targets for therapies, and apply these genes to ancillary research and allocation factors in clinical trials."},"methods":{"ja":"RNA-seq解析","en":"RNA-seq analysis"},"targets":{"ja":"グリオーマ124症例の新鮮凍結組織","en":"A total of 124 fresh-frozen tumor tissues from 124 patients with glioma"},"url":{"ja":[{"url":"https://www.ncc.go.jp/jp/ncch/division/rcc/rcgrant/0015/index.html","text":"https://www.ncc.go.jp/jp/ncch/division/rcc/rcgrant/0015/index.html"}],"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"グリオーマ：124症例\n（日本人）","en":"glioma: 124 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（RNA-seq）","en":"NGS\n(RNA-seq)"}},"releaseNote":{"ja":"グリオーマ124症例の新鮮凍結組織中の腫瘍組織124検体より抽出したRNAを用いたRNA-seq解析データをfastqファイルにて提供する。","en":"RNAs extracted from fresh frozen tumor tissues from 124 patients with glioma were used for RNA-sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"高阪 真路","en":"Shinji Kohsaka"},"organization":{"name":{"ja":"国立がん研究センター 細胞情報学分野","en":"Division of Cellular Signaling, National Cancer Center Research Institute"}}}],"researchProjects":[],"grants":[{"title":{"ja":"AYA世代および壮年世代の悪性脳腫瘍における新規治療標的探索","en":"Exploration of Novel Therapeutic Targets in Malignant Brain Tumors of the AYA and Late Middle Age"},"agency":{"ja":"国立がん研究センター希少がんグラント","en":"Grant-in-Aid for Rare Cancer Research, National Cancer Center"},"grantIds":["1-7"]}],"relatedPublications":[{"title":"The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma","doi":"https://doi.org/10.1007/s11060-024-04563-z","datasets":["JGAD000801"]}],"datasets":["JGAD000801"],"controlledAccessUsers":[]}