{"id":"hum0418","version":1,"url":"https://humandbs.dbcls.jp/research/hum0418/v1","datePublished":"2025-02-17","versions":[{"version":1,"datePublished":"2025-02-17"}],"title":{"ja":"がん患者の臨床検体を用いた、治療効果および毒性に関する遺伝子のプロファイリング研究","en":"Trial of Onco-Panel for Geneprofiling to Estimate both Adverse events and Response by cancer treatment (TOP-GEAR)"},"summary":{"aims":{"ja":"腫瘍組織および非腫瘍組織（末梢血）の遺伝子プロファイリングを行うことにより、治療効果および毒性に関連する体細胞遺伝子変異、遺伝子発現ならびに遺伝子多型の同定を行う","en":"Genome profiling to estimate both adverse events and response of chemotherapy in cancer patients"},"methods":{"ja":"次世代シークエンサーを用いたゲノムプロファイリング","en":"Genome profiling using next generation sequencers"},"targets":{"ja":"抗悪性腫瘍薬による治療を予定している患者","en":"Cancer patient who will receive chemotherapy"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"配列決定","en":"Sequencing"},"targets":{"ja":"抗悪性腫瘍薬による治療を予定している癌患者：507症例\n（日本人）","en":"Cancer patient who will receive chemotherapy: 507 cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（Target Capture）","en":"NGS\n(Target Capture)"}},"releaseNote":{"ja":"抗悪性腫瘍薬による治療を予定しているがん患者507名の腫瘍組織および非腫瘍組織（末梢血）から抽出したDNAを用いたNCCオンコパネル検査（114遺伝子）データをfastqおよびbamファイルにて提供する。","en":"DNAs extracted from tumor tissues and peripheral blood cells of 507 patients who will receive chemotherapy were used for the target capture sequencing analysis. Fastq and bam files are provided."},"dataProviders":[{"name":{"ja":"河野 隆志","en":"Takashi Kohno"},"organization":{"name":{"ja":"国立がん研究センター研究所 ゲノム生物学研究分野","en":"Division of Genome Biology, National Cancer Center Research Institute"}}}],"researchProjects":[{"name":{"ja":"TOP-GEARプロジェクト","en":"TOP-GEAR Project"},"url":{"ja":[{"url":"https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000013046","text":"https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000013046"}],"en":[{"url":"https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000013046","text":"https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000013046"}]}}],"grants":[{"title":{"ja":"ゲノム創薬・医療を指向した全国規模の進行固形がん、及び、遺伝性腫瘍臨床ゲノムデータストレージの構築","en":"Pan-Japan storage of clinical and genomic information on advanced solid and hereditary cancers for precision cancer medicine"},"agency":{"ja":"日本医療研究開発機構（AMED） 臨床ゲノム情報統合データベース整備事業","en":"Program for an Integrated Database of Clinical and Genomic Information, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP18kk0205004"]}],"relatedPublications":[{"title":"Feasibility and utility of a panel testing for 114 cancer-associated genes in a clinical setting: A hospital-based study","doi":"https://doi.org/10.1111/cas.13969","datasets":["JGAD000792"]},{"title":"A computational tool to detect DNA alterations tailored to formalin-fixed paraffin-embedded samples in cancer clinical sequencing","doi":"https://doi.org/10.1186/s13073-018-0547-0","datasets":["JGAD000792"]}],"datasets":["JGAD000792"],"controlledAccessUsers":[]}