{"id":"hum0413","version":2,"url":"https://humandbs.dbcls.jp/research/hum0413/v2","datePublished":"2025-03-24","versions":[{"version":1,"datePublished":"2023-07-20"},{"version":2,"datePublished":"2025-03-24"}],"title":{"ja":"アトピー性皮膚炎患者の網羅的データ解析研究","en":"Comprehensive analysis on medical and omics data from patients with atopic dermatitis"},"summary":{"aims":{"ja":"膨大なデータを蓄積・解析することで、発症予測・予防・治療法の選択など、医療戦略に貢献することを目的とする。アレルギー疾患をモデルとして計算科学分野を中核に、異分野の研究を融合させた新たな研究分野の創成を目指し、知識基盤として疾患ビッグデータ解析技術の開発と疾患メカニズム研究を行う。","en":"To contribute to medical strategies involving disease prediction, prevention, and treatment selection through collecting and analyzing human omics data. We strive to create a novel research field that integrates interdisciplinary studies, with a focus on computational science, using allergy disorders as a model."},"methods":{"ja":"RNA-seq解析","en":"RNA-seq analysis"},"targets":{"ja":"アトピー性皮膚炎 161＋41症例（皮膚組織：260＋762検体、末梢血単核細胞［PBMC］：461検体）\n乾癬 18症例（皮膚組織：36検体）\n健常者 41＋10名（皮膚組織：55＋19検体、PBMC：41検体）","en":"Atopic dermatitis 161 + 41 cases (skin tissue: 260 + 762 samples, PBMC: 461 samples)\nPsoriasis: 18 cases (skin tissue: 36 samples)\n41 + 10 healthy controls (skin tissue: 55 + 19 samples, PBMC: 41 samples)"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"アトピー性皮膚炎：161＋41症例\n乾癬：18症例\n健常者：41＋10名\n（日本人）","en":"Atopic dermatitis: 161 + 41 cases\nPsoriasis: 18 cases\n41 + 10 healthy controls\n(Japanese)"},"typeOfData":{"ja":"NGS\n（RNA-seq）","en":"NGS\n(RNA-seq)"}},"releaseNote":{"ja":"アトピー性皮膚炎156症例、乾癬18症例、健常者26名の皮膚組織から抽出したRNAを用いたRNA-seq解析データをfastqファイルにて提供する。","en":"RNAs extracted from skin tissues from 156 atopic dermatitis cases, 18 psoriasis and 26 healthy controls were used for RNA-sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"古関 明彦","en":"Haruhiko Koseki"},"organization":{"name":{"ja":"理化学研究所 生命医科学研究センター 免疫器官形成研究チーム","en":"Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences"}}}],"researchProjects":[{"name":{"ja":"アトピー性皮膚炎患者の網羅的データ解析研究","en":"Comprehensive analysis on medical and omics data from patients with atopic dermatitis."},"url":{"ja":null,"en":null}}],"grants":[{"title":{"ja":"臨床・オミクス情報の統合解析による、アトピー性皮膚炎とそれに併発する他臓器アレルギー疾患の病態解明","en":"Elucidation of pathology of atopic dermatitis involving multiple organ allergy by integrating clinical and omics information"},"agency":{"ja":"国立研究開発法人日本医療研究開発機構（AMED） 免疫アレルギー疾患実用化研究事業","en":"Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP22ek0410079"]},{"title":{"ja":"アトピー性皮膚炎の個別化予測医療を目指した皮膚微生物叢解析研究","en":"Analysis on skin microbiome for establishment of precision medicine in atopic dermatitis"},"agency":{"ja":"国立研究開発法人日本医療研究開発機構（AMED） 免疫アレルギー疾患実用化研究事業","en":"Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP21ek0410058"]},{"title":{"ja":"アトピー性皮膚炎の個別化医療・予測医療実現に向けた、皮膚トランスクリプトーム解析研究","en":"Analysis on skin transcriptome for establishment of precision medicine in atopic dermatitis"},"agency":{"ja":"国立研究開発法人日本医療研究開発機構（AMED） 免疫アレルギー疾患実用化研究事業","en":"Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP19ek0410046"]},{"title":{"ja":"皮膚・腸内微生物叢解析によるアトピー性皮膚炎発症機序の解明","en":"Elucidation of mechanisms underlying progression of atopic dermatitis by analysis on skin and gut microbiome"},"agency":{"ja":"国立研究開発法人日本医療研究開発機構（AMED） 免疫アレルギー疾患実用化研究事業","en":"Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP18ek0410028"]},{"title":{"ja":"高精度の予測に基づく予防医療の実現に向けた疾患ビッグデータ主導型イノベーションハブ","en":"Hub for Predictive and Preventative Precision Medicine Driven by Big Data"},"agency":{"ja":"科学技術振興機構（JST） イノベーションハブ構築支援事業","en":"Project for Development of Innovation Hub, Japan Science and Technology Agency (JST)"},"grantIds":["JPMJIH1504"]},{"title":{"ja":"皮膚微生物叢と宿主の双方向理解に基づくアトピー性皮膚炎の新規治療の創出","en":"Innovation of microbial treatment for atopic dermatitis based on bidirectional understanding of skin microbiota and host"},"agency":{"ja":"国立研究開発法人日本医療研究開発機構（AMED） 免疫アレルギー疾患実用化研究事業","en":"Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP22ek0410098"]},{"title":{"ja":"アレルギー病態の多様性の解明と持続可能なデータ駆動型精密医療の実現を目指した、アトピー性皮膚炎を対象とする異分野融合研究","en":"Interdisciplinary research on atopic dermatitis to elucidate the diversity of allergic pathophysiology and to realize sustainable data-driven precision medicine"},"agency":{"ja":"国立研究開発法人日本医療研究開発機構（AMED） 免疫アレルギー疾患実用化研究事業","en":"Practical Research Project for Allergic Diseases and Immunology, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP23ek0410118"]}],"relatedPublications":[{"title":"Multifaceted analysis of cross-tissue transcriptomes reveals phenotype-endotype associations in atopic dermatitis.","doi":"https://doi.org/10.1038/s41467-023-41857-8","datasets":["JGAD000757"]}],"datasets":["JGAD000757","JGAD000922"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000757","JGAD000922"]},{"principalInvestigator":{"ja":"古賀 敬子","en":"Keiko Koga"},"affiliation":{"ja":"リサーチ　ターゲットバリデーションサイエンシズ, 武田薬品工業株式会社","en":"Takeda Pharmaceutical Company"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"アトピー性皮膚炎患者（および乾癬患者、健常者）由来皮膚組織およびPBMCの公開RNA-seqデータを用いたアトピー性皮膚炎治療薬標的の探索","en":"Exploration of therapeutic drug targets for atopic dermatitis using publicly available RNA-seq data from skin tissues and PBMCs derived from patients with atopic dermatitis (and psoriasis and healthy subjects)"},"periodStart":"2025-08-18","periodEnd":"2028-07-20","datasets":["JGAD000757","JGAD000922"]},{"principalInvestigator":{"ja":"中溝 聡","en":"Satoshi Nakamizo"},"affiliation":{"ja":"皮膚科, 京都大学","en":"Dermatology, Kyoto University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"免疫・アレルギー性皮膚疾患の免疫学的解析","en":"Immunological Analysis of Immune-Mediated and Allergic Skin Diseases"},"periodStart":"2026-04-06","periodEnd":"2028-03-31","datasets":["JGAD000757","JGAD000922"]}]}