{"id":"hum0390","version":1,"url":"https://humandbs.dbcls.jp/research/hum0390/v1","datePublished":"2023-06-30","versions":[{"version":1,"datePublished":"2023-06-30"}],"title":{"ja":"ゲノム・エピゲノム解析による慢性子宮内膜炎の関連遺伝子の解明とその診断法および治療法の検討","en":"Elucidation of genetic factors associated with chronic endometritis (CE) through genomic and epigenomic analyses, and investigation on novel diagnostic and therapeutic methods for CE"},"summary":{"aims":{"ja":"妊娠の成立と維持に必要な組織および細胞の網羅的なゲノム・エピゲノム解析を行い、生殖と発生に関わる成育疾患の研究基盤となる知見を確立する。","en":"To establish a knowledge basis for human reproduction and development by conducting genomic and epigenomic analyses on the cells and tissues of organs essential for pregnancy."},"methods":{"ja":"子宮内膜組織片から抽出したRNAを用いたRNAシーケンス解析","en":"Total RNA samples from endometrial tissues were subjected to RNA sequencing analysis."},"targets":{"ja":"慢性子宮内膜炎症例とコントロール（非慢性子宮内膜炎症例）から採取した子宮内膜組織片","en":"Endometrial tissues from chronic endometritis cases and control cases"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"慢性子宮内膜炎：24症例\n対照者：33名\n（日本人）","en":"chronic endometritis: 24 cases\n33 controls\n(Japanese)"},"typeOfData":{"ja":"NGS\n（RNA-seq）","en":"NGS\n(RNA-seq)"}},"releaseNote":{"ja":"慢性子宮内膜炎24症例と非慢性子宮内膜炎33症例の子宮内膜組織片から抽出したRNAを用いたRNA-seq解析データをfastqファイルにて提供する","en":"RNAs extracted from endometrial tissues of 24 chronic endometritis cases and 33 controls were used for RNA-sequencing analysis. Fastq files are provided."},"dataProviders":[{"name":{"ja":"黒田 恵司","en":"Keiji Kuroda"},"organization":{"name":{"ja":"杉山産婦人科丸の内 生殖医療科","en":"Center for Reproductive Medicine and Endoscopy, Sugiyama Clinic Marunouchi"}}}],"researchProjects":[],"grants":[{"title":{"ja":"精緻エピゲノム解析技術開発とIRUD未解明症例への応用","en":"Diagnosis of rare diseases and elucidation of molecular pathological states by using epigenetic information"},"agency":{"ja":"日本医療研究開発機構（AMED） 難治性疾患実用化研究事業","en":"Practical Research Project for Rare/Intractable Diseases, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP22ek0109489"]}],"relatedPublications":[{"title":"Gene expression signatures associated with chronic endometritis revealed by RNA sequencing","doi":"https://doi.org/10.3389/fmed.2023.1185284","datasets":["JGAD000750"]}],"datasets":["JGAD000750"],"controlledAccessUsers":[]}