{"id":"hum0379","version":1,"url":"https://humandbs.dbcls.jp/research/hum0379/v1","datePublished":"2023-11-20","versions":[{"version":1,"datePublished":"2023-11-20"}],"title":{"ja":"制御性T細胞特異的エピゲノム誘導による免疫制御の研究","en":"Immune regulation by cotrolling regulatory T cell-specific epigenome"},"summary":{"aims":{"ja":"自己免疫疾患における免疫担当細胞の解析","en":"Analysis of immune cells in autoimmune diseases"},"methods":{"ja":"single-cell RNA-seqおよびsingle-cell VDJ-seq","en":"single-cell RNA+VDJ-seq"},"targets":{"ja":"重症筋無力症（myasthenia gravis：MG） 2症例、多発性硬化症（multiple sclerosis：MS）4症例、全身性エリテマトーデス（systemic lupus erythematosus：SLE）3症例、健常者3名","en":"myasthenia gravis (MG) 2 cases, multiple sclerosis (MS) 4 cases, systemic lupus erythematosus (SLE) 3 cases, 3 healthy cases"},"url":{"ja":null,"en":null}},"listingSummary":{"methods":{"ja":"発現","en":"Expression profiling"},"targets":{"ja":"重症筋無力症：2症例\n多発性硬化症：4症例\n全身性エリテマトーデス：3症例\n健常者：3名\n（日本人）","en":"myasthenia gravis: 2 cases\nmultiple sclerosis: 4 cases\nsystemic lupus erythematosus: 3 cases\n3 healthy cases\n(Japanese)"},"typeOfData":{"ja":"NGS\n（scRNA-seq、scVDJ-seq）","en":"NGS\n(scRNA-seq, scVDJ-seq)"}},"releaseNote":{"ja":"重症筋無力症2症例、多発性硬化症4症例、全身性エリテマトーデス3症例、健常者3名の末梢血由来CD4+T細胞およびB細胞から抽出したRNAを用いたscRNA-seq解析ならびにscVDJ-seq解析の結果をfastqファイル形式で提供する。","en":"RNAs extracted from CD4+ T cell and B cell isolated from peripheral blood of 2 myasthenia gravis patients, 4 multiple sclerosis patients, 3 systemic lupus erythematosus patients and 3 healthy cases were used for the single-cell RNA sequencing and single-cell VDJ sequencing analyses. Fastq files are provided."},"dataProviders":[{"name":{"ja":"坂口 志文","en":"Shimon Sakaguchi"},"organization":{"name":{"ja":"大阪大学 免疫学フロンティア研究センター 実験免疫学","en":"Experimental Immunology, IFReC, Osaka University"}}}],"researchProjects":[],"grants":[{"title":{"ja":"制御性T細胞による免疫応答制御の包括的研究","en":"Study of the function and development of regulatory T cells"},"agency":{"ja":"科学研究費助成事業 特別推進研究","en":"KAKENHI Grant-in-Aid for Specially Promoted Research"},"grantIds":["16H06295"]},{"title":{"ja":"制御性T細胞を標的とした免疫応答制御技術に関する研究開発","en":"Study of Immunoregulatory technology targeting regulatory T cells"},"agency":{"ja":"日本医療研究開発機構（AMED） 革新的先端研究開発支援事業 インキュベートタイプ（LEAP）","en":"Leading Advanced Projects for medical innovation (LEAP), Advanced Research & Development Programs for Medical Innovation, Japan Agency for Medical Research and Development (AMED)"},"grantIds":["JP18gm0010005"]}],"relatedPublications":[],"datasets":["JGAD000704"],"controlledAccessUsers":[{"principalInvestigator":{"ja":"浜田 道昭","en":"Michiaki Hamada"},"affiliation":{"ja":"浜田研究室, 理工学術院, 早稲田大学","en":"Hamada Laboratory, Faculty of Science and Engineering, Waseda University"},"country":{"ja":"日本","en":"Japan"},"researchTitle":{"ja":"RNA標的創薬データベースの構築","en":"Construction of RNA-targeted Drug Discovery Database"},"periodStart":"2023-01-05","periodEnd":"2027-10-31","datasets":["JGAD000704"]}]}